Computational Design of a Protein-Based Enzyme Inhibitor
about
Why reinvent the wheel? Building new proteins based on ready-made partsA Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected CellsDe novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificityAchievements and Challenges in Computational Protein Design.An Evolution-Based Approach to De Novo Protein Design.Inferring the microscopic surface energy of protein-protein interfaces from mutation data.Control of repeat-protein curvature by computational protein design.Measuring the activity of protein variants on a large scale using deep mutational scanning.Deep mutational scanning: a new style of protein scienceComputational design and experimental verification of a symmetric protein homodimer.Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex.Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design.Scratching the Surface: Resurfacing Proteins to Endow New Properties and Function.An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.An improved Protein G with higher affinity for human/rabbit IgG Fc domains exploiting a computationally designed polar network.Designer protein delivery: From natural to engineered affinity-controlled release systems.Ni(II)-Schiff base complex as an enzyme inhibitor of hen egg white lysozyme: a crystallographic and spectroscopic study.Affinity Maturation of a Cyclic Peptide Handle for Therapeutic Antibodies Using Deep Mutational Scanning.The power of multiplexed functional analysis of genetic variants.A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences.A "fuzzy"-logic language for encoding multiple physical traits in biomolecules.Protein-protein interactions in paralogues: Electrostatics modulates specificity on a conserved steric scaffold.Sampling and energy evaluation challenges in ligand binding protein design.Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity.Creation of artificial protein-protein interactions using α-helices as interfaces.Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning.Multiplexed assays of variant effects contribute to a growing genotype-phenotype atlas
P2860
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P2860
Computational Design of a Protein-Based Enzyme Inhibitor
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Computational Design of a Protein-Based Enzyme Inhibitor
@ast
Computational Design of a Protein-Based Enzyme Inhibitor
@en
Computational Design of a Protein-Based Enzyme Inhibitor
@nl
type
label
Computational Design of a Protein-Based Enzyme Inhibitor
@ast
Computational Design of a Protein-Based Enzyme Inhibitor
@en
Computational Design of a Protein-Based Enzyme Inhibitor
@nl
prefLabel
Computational Design of a Protein-Based Enzyme Inhibitor
@ast
Computational Design of a Protein-Based Enzyme Inhibitor
@en
Computational Design of a Protein-Based Enzyme Inhibitor
@nl
P2093
P2860
P50
P1476
Computational Design of a Protein-Based Enzyme Inhibitor
@en
P2093
Gregory Kornhaber
James Aramini
John F Hunt
Keith Hamilton
Rickard Hedman
P2860
P304
P356
10.1016/J.JMB.2013.06.035
P407
P577
2013-09-23T00:00:00Z