Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors - Test2 - elhamkhani - TriplyDB

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

http://www.wikidata.org/entity/Q27681896

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Studying epigenetic complexes and their inhibitors with the proteomics toolbox The bromodomain: from epigenome reader to druggable target A Cell Biologist's Field Guide to Aurora Kinase Inhibitors Selective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage Progression Comprehensive characterization of the Published Kinase Inhibitor Set Targeting BET bromodomains for cancer treatment Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules Drug Discovery Targeting Bromodomain-Containing Protein 4.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor Fragment-based screening of the bromodomain of ATAD2.Fluorinated aromatic amino acids are sensitive 19F NMR probes for bromodomain-ligand interactions.Nonequivalent response to bromodomain-targeting BET inhibitors in oligodendrocyte cell fate decision.BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536 Molecular docking and dynamics simulation study of flavonoids as BET bromodomain inhibitors.Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET.Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.High level of BRD4 promotes non-small cell lung cancer progression.ERK5 kinase activity is dispensable for cellular immune response and proliferation.Cyclin-dependent kinase inhibitors as marketed anticancer drugs: where are we now? A short survey.Addressing the right targets in oncology: challenges and alternative approaches.Inhibitors of emerging epigenetic targets for cancer therapy: a patent review (2010-2014).Progress towards a public chemogenomic set for protein kinases and a call for contributions.Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.BRD4 promotes gastric cancer progression through the transcriptional and epigenetic regulation of c-MYC.BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.Selective targeting of epigenetic reader domains.BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Molecular Pathways: Targeting the PI3K Pathway in Cancer-BET Inhibitors to the Rescue Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals.Targeting Cancer Cells with BET Bromodomain Inhibitors.Non-kinase targets of protein kinase inhibitors.Playing polo during mitosis: PLK1 takes the lead.Detecting similar binding pockets to enable systems polypharmacology.An iridium(iii)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent.Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations.Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia.Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics.

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Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

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2014 nî lūn-bûn

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2014年の論文

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ACS Chemical Biology

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Acetyl-lysine Binding Site of ...... with Diverse Kinase Inhibitors

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Andreas Becker

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Ernst Schönbrunn

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Jin-Yi Zhu

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Norbert Berndt

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P2860

The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK

Selective inhibition of BET bromodomains

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

Histone recognition and large-scale structural analysis of the human bromodomain family

Small-molecule inhibition of BRDT for male contraception.

The role of human bromodomains in chromatin biology and gene transcription

MolProbity: all-atom structure validation for macromolecular crystallography

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

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1160-71

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59689

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10.1021/CB500072Z

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5

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24568369

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