Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy
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Slow-Onset Inhibition of Mycobacterium tuberculosis InhA: Revealing Molecular Determinants of Residence Time by MD SimulationsRadiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureusDirect inhibitors of InhA are active against Mycobacterium tuberculosis.Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase.Aqueous Molecular Dynamics Simulations of the M. tuberculosis Enoyl-ACP Reductase-NADH System and Its Complex with a Substrate Mimic or Diphenyl Ethers Inhibitors.Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.Mycobacterium tuberculosis enoyl-acyl carrier protein reductase inhibitors as potential antituberculotics: development in the past decade.Recent Advances and Structural Features of Enoyl-ACP Reductase Inhibitors of Mycobacterium tuberculosis.New structural classes of antituberculosis agents.Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.Identification of InhA inhibitors: A combination of virtual screening, molecular dynamics simulations and quantum chemical studies.
P2860
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P2860
Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@ast
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@en
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@nl
type
label
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@ast
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@en
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@nl
prefLabel
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@ast
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@en
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@nl
P2093
P2860
P50
P356
P1433
P1476
Time-Dependent Diaryl Ether In ...... Activity, and in vivo Efficacy
@en
P2093
Carlos Simmerling
Gopal R Bommineni
Huei-Jiun Li
Miguel Garcia-Diaz
Sachindra S Patil
Susan E Knudson
P2860
P304
P356
10.1002/CMDC.201300429
P577
2014-04-01T00:00:00Z