Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming - Test2 - elhamkhani - TriplyDB

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

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Ubc13: the Lys63 ubiquitin chain building machine RBR E3 ubiquitin ligases: new structures, new insights, new questions Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase Molecular basis for specificity of the Met1-linked polyubiquitin signal Perilous journey: a tour of the ubiquitin-proteasome system USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7 Structural and functional insights to ubiquitin-like protein conjugation.Mechanisms of generating polyubiquitin chains of different topology.Assembly and specific recognition of k29- and k33-linked polyubiquitin.Versatile roles of k63-linked ubiquitin chains in trafficking.Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.Covalent Tethering of Fragments For Covalent Probe Discovery The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.Using protein motion to read, write, and erase ubiquitin signals.A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism Targeting ubiquitination for cancer therapies.Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3.Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.Specificity and disease in the ubiquitin system Activity-Based Probes for HECT E3 Ubiquitin Ligases The increasing complexity of the ubiquitin code.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases.Linear ubiquitin chains: enzymes, mechanisms and biology Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation.Bimolecular Fluorescence Complementation to Assay the Interactions of Ubiquitylation Enzymes in Living Yeast Cells.Genome-wide identification and evolution of HECT genes in soybean.Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes.Structure of the HECT domain of human WWP2.Caught in the act.A conformational switch regulates the ubiquitin ligase HUWE1.Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases.UbFluor: A Mechanism-Based Probe for HECT E3 Ligases.Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development.Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.

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Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

http://www.wikidata.org/entity/Q27684556

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2013 nî lūn-bûn

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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2013年の論文

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Structure of a ubiquitin-loade ...... ar basis for catalytic priming

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Structure of a ubiquitin-loade ...... ar basis for catalytic priming

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Structure of a ubiquitin-loade ...... ar basis for catalytic priming

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Structure of a ubiquitin-loade ...... ar basis for catalytic priming

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Structure of a ubiquitin-loade ...... ar basis for catalytic priming

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Structure of a ubiquitin-loade ...... ar basis for catalytic priming

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Structure of a ubiquitin-loade ...... ar basis for catalytic priming

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Structure of a ubiquitin-loade ...... ar basis for catalytic priming

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Nature Structural & Molecular Biology

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Structure of a ubiquitin-loade ...... ar basis for catalytic priming

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P2093

Elena Maspero

http://www.w3.org/2001/XMLSchema#string

Eleonora Valentini

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Paolo Soffientini

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Sara Mari

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Simona Polo

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P2860

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

PHENIX: a comprehensive Python-based system for macromolecular structure solution

The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

Structure and function of a HECT domain ubiquitin-binding site

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

Phasercrystallographic software

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6

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20

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Sebastiano Pasqualato

Valentina Cecatiello

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2013-06-01T00:00:00Z

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236638629

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1018171483

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23644597

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