RBR E3 ubiquitin ligases: new structures, new insights, new questions - Test2 - elhamkhani - TriplyDB

RBR E3 ubiquitin ligases: new structures, new insights, new questions

RBR E3 ubiquitin ligases: new structures, new insights, new questions

http://www.wikidata.org/entity/Q26828565

about

Ubc13: the Lys63 ubiquitin chain building machine Drugging the undruggables: exploring the ubiquitin system for drug development Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways Expanding the ubiquitin code through post-translational modification The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease Parkin structure and function Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 Molecular basis for specificity of the Met1-linked polyubiquitin signal Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases Structural insights into Parkin substrate lysine targeting from minimal Miro substrates Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.The ubiquitination machinery of the ubiquitin system.Parkin regulates kainate receptors by interacting with the GluK2 subunit Bio-Zombie: the rise of pseudoenzymes in biology.Cullin E3 ligases and their rewiring by viral factors A polyubiquitin chain reaction: parkin recruitment to damaged mitochondria Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination A new scheme to discover functional associations and regulatory networks of E3 ubiquitin ligases.Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain Ubiquitination in the antiviral immune response Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system.Deubiquitinases and the new therapeutic opportunities offered to cancer.Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination.Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.Specificity and disease in the ubiquitin system Recent advances in SCF ubiquitin ligase complex: Clinical implications Activity-Based Probes for HECT E3 Ubiquitin Ligases Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.Post-translational control of NF-κB signaling by ubiquitination.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Conventional and unconventional ubiquitination in plant immunity.Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.

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P2860

RBR E3 ubiquitin ligases: new structures, new insights, new questions

http://www.wikidata.org/entity/Q26828565

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

RBR E3 ubiquitin ligases: new structures, new insights, new questions

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

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Biochemical Journal

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

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Helen Walden

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Creative Commons Attribution 3.0 Unported

P2860

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor

The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity

Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7

N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8

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421-437

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scholarly article

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1806838

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10.1042/BJ20140006

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3

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458

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Donald E Spratt

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2014-03-15T00:00:00Z

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24576094

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3940038

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