Parkinson's disease and immune system: is the culprit LRRKing in the periphery? - Test2 - elhamkhani - TriplyDB

Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

http://www.wikidata.org/entity/Q27687171

about

GTP binding controls complex formation by the human ROCO protein MASL1 The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death.Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein.Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD).Association Between Parkinson's Disease and Inflammatory Bowel Disease: a Nationwide Taiwanese Retrospective Cohort Study.A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis.Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.LRRKing up the right trees? On figuring out the effects of mutant LRRK2 and other Parkinson's disease-related genes.LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.Leucine Rich Repeat Kinase 2: beyond Parkinson's and beyond kinase inhibitors.

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

http://www.wikidata.org/entity/Q27687171

description

2012 nî lūn-bûn

@nan

2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

@zh-hk

2012年論文

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2012年論文

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2012年论文

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name

Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

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Journal of Neuroinflammation

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

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Laura Civiero

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Marco Bisaglia

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Creative Commons Attribution 2.0 Generic

P2860

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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9

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Parkinson's disease

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