K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac - Test2 - elhamkhani - TriplyDB

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist Two-pore Domain Potassium Channels in Astrocytes An overview of heavy-atom derivatization of protein crystals Mechanically Activated Ion Channels Piezo1 Channels Are Inherently Mechanosensitive Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states Early-life serotonin dysregulation affects the migration and positioning of cortical interneuron subtypes.Markov modeling reveals novel intracellular modulation of the human TREK-2 selectivity filter.Tandem malonate-based glucosides (TMGs) for membrane protein structural studies.Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.Scanning MscL Channels with Targeted Post-Translational Modifications for Functional Alterations.Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy.Calcium ions open a selectivity filter gate during activation of the MthK potassium channel Genome-Wide Transcriptome Analysis of CD36 Overexpression in HepG2.2.15 Cells to Explore Its Regulatory Role in Metabolism and the Hepatitis B Virus Life Cycle Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore.Modulation of Potassium Channels Inhibits Bunyavirus Infection.Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel.A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties.Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.Functional Annotation of Ion Channel Structures by Molecular Simulation.Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region.Much more than a leak: structure and function of K₂p-channels.A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels.Structure of potassium channels.How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.Concentration-Dependent Binding of Small Ligands to Multiple Saturable Sites in Membrane Proteins.K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia?GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels.Serotonergic agents act on 5-HT3 receptors in the brain to block seizure-induced respiratory arrest in the DBA/1 mouse model of SUDEP.Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels.Exploring the Dynamics of the TWIK-1 Channel.An allosteric ligand-binding site in the extracellular cap of K2P channels.Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.Asymmetric mechanosensitivity in a eukaryotic ion channel.The effects of stretch activation on ionic selectivity of the TREK-2 K2P K+ channel.Grafting voltage and pharmacological sensitivity in potassium channels

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P2860

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

http://www.wikidata.org/entity/Q27698483

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2015 nî lūn-bûn

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2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

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Alexandra Mackenzie

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Liang Dong

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Lishuang Cao

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Mariana Grieben

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Mark S P Sansom

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Michael V Clausen

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Nicola A Burgess-Brown

http://www.w3.org/2001/XMLSchema#string

Prafulla Aryal

http://www.w3.org/2001/XMLSchema#string

Shubhashish Mukhopadhyay

http://www.w3.org/2001/XMLSchema#string

Solenne Goubin

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P2860

Crystal structure of the human two-pore domain potassium channel K2P1

Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel

MolProbity: all-atom structure validation for macromolecular crystallography

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine

PROMOTIF--a program to identify and analyze structural motifs in proteins

Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.

Inference of macromolecular assemblies from crystalline state

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1256-1259

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347

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Stephen J. Tucker

Gian Filippo Ruda

Conor McClenaghan

Elisabeth P Carpenter

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2015-03-01T00:00:00Z

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273631654

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