Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
about
FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1.Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening.Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides.The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication
P2860
Q33787365-63BA95F4-E666-4479-9498-018774732B1AQ33851243-E8243727-ECDE-4691-9B8D-9BB453A8CFECQ36409202-7A2D10EB-B88A-4FE7-83D1-2B92A54F7D6BQ37712232-F8110A76-981C-4336-B863-5475F4EF1E8AQ38689827-CE387589-0C45-42B6-8E1C-038764E8FB23Q38695987-7149D971-3E25-4D76-8A13-678F5E81540AQ55332403-6F9BA4AA-021F-4C88-991A-B63AD361A290Q55368890-A90E6ACD-BB0A-4FED-93B0-CA2553E3E215Q58859255-A6D3DAFD-6B07-4529-A3BE-7B529744FA1F
P2860
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
description
2016 nî lūn-bûn
@nan
2016 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@ast
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@en
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@en-gb
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@nl
type
label
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@ast
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@en
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@en-gb
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@nl
prefLabel
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@ast
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@en
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@en-gb
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@nl
P2093
P2860
P50
P356
P1154
2-s2.0-84982162361
P1476
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
@en
P2093
Catrine L B Siöberg
Claire McWhirter
Clifford D Jones
J Willem M Nissink
Jack C Exell
Jane A Grasby
Judit Debreczeni
L David Finger
Mark J Thompson
Stephen T Durant
P2860
P2888
P304
P356
10.1038/NCHEMBIO.2148
P5530
P577
2016-10-01T00:00:00Z
P6179
1019197973