Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes
about
The NEDD8 modification pathway in plantsThe amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neuronsParkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimerA unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8COP9-associated CSN5 regulates exosomal protein deubiquitination and sortingTRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexesStructural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1.Proximity-induced activation of human Cdc34 through heterologous dimerization.The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like proteinSystematic and quantitative assessment of the ubiquitin-modified proteomeStructural analysis of UBL5, a novel ubiquitin-like modifierUbiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathwaysStructural determinants for the binding of ubiquitin-like domains to the proteasomeSubstrate specificity of the ubiquitin and Ubl proteasesInhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapyStructural studies of molybdopterin synthase provide insights into its catalytic mechanismInsights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinityStructural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8’s E1 † ‡Structural Basis for Ubiquitin Recognition by a Novel Domain from Human Phospholipase A2-activating Protein60th residues of ubiquitin and Nedd8 are located out of E2-binding surfaces, but are important for K48 ubiquitin-linkageInsights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virusRegulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteinsUbiquitylation, neddylation and the DNA damage responseThe Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptorThe ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditionsSolution structure of Urm1 and its implications for the origin of protein modifiersNEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradationCharacterizing ubiquitination sites by peptide-based immunoaffinity enrichment.Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeastIdentification of a multifunctional binding site on Ubc9p required for Smt3p conjugation.The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe.Nedd8 on cullin: building an expressway to protein destruction.Creation of a pluripotent ubiquitin-conjugating enzyme.Protein neddylation: beyond cullin-RING ligases.The molecular determinants of NEDD8 specific recognition by human SENP8.
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P2860
Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Crystal structure of the human ...... with ubiquitin pathway enzymes
@ast
Crystal structure of the human ...... with ubiquitin pathway enzymes
@en
Crystal structure of the human ...... with ubiquitin pathway enzymes
@nl
type
label
Crystal structure of the human ...... with ubiquitin pathway enzymes
@ast
Crystal structure of the human ...... with ubiquitin pathway enzymes
@en
Crystal structure of the human ...... with ubiquitin pathway enzymes
@nl
prefLabel
Crystal structure of the human ...... with ubiquitin pathway enzymes
@ast
Crystal structure of the human ...... with ubiquitin pathway enzymes
@en
Crystal structure of the human ...... with ubiquitin pathway enzymes
@nl
P2093
P2860
P3181
P356
P1476
Crystal structure of the human ...... with ubiquitin pathway enzymes
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.273.52.34983
P407
P577
1998-12-25T00:00:00Z