Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol - Test2 - elhamkhani - TriplyDB

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol

http://www.wikidata.org/entity/Q24336876

about

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate Targeting cellular metabolism to improve cancer therapeutics Redox-directed cancer therapeutics: molecular mechanisms and opportunities Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex Targeting Cancer Metabolism - Revisiting the Warburg Effects Novel drugs that target the metabolic reprogramming in renal cell cancer Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains.Structural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2 Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4 Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket Pro-haloacetate Nanoparticles for Efficient Cancer Therapy via Pyruvate Dehydrogenase Kinase Modulation Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104 Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency.Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate.Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza The pyruvate dehydrogenase complexes: structure-based function and regulation.Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells.Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma.Role of pyruvate dehydrogenase kinase 4 in regulation of blood glucose levels.Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonance Emerging metabolic targets in cancer therapy Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation MondoA deficiency enhances sprint performance in mice.Potential compounds for the treatment of mitochondrial disease.Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation.Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy.Anticancer agents that counteract tumor glycolysis.Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases.Monitoring phosphorylation of the pyruvate dehydrogenase complex.Crosstalk among proteome, acetylome and succinylome in colon cancer HCT116 cell treated with sodium dichloroacetate Elevated acetyl-CoA by amino acid recycling fuels microalgal neutral lipid accumulation in exponential growth phase for biofuel production.Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H₂O₂--implications for their role in disease, especially cancer.Mitochondrial metabolism inhibitors for cancer therapy.PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages.Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.

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P2860

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol

http://www.wikidata.org/entity/Q24336876

description

2007 nî lūn-bûn

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2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2007 թվականի օգոստոսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Distinct Structural Mechanisms ...... Dichloroacetate, and Radicicol

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

@ast

Distinct structural mechanisms ...... dichloroacetate, and radicicol

@en

Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

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J.STR.2007.07.001

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Distinct structural mechanisms ...... dichloroacetate, and radicicol

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Jacinta L Chuang

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Jun Li

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Masato Kato

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P2860

Marked differences between two isoforms of human pyruvate dehydrogenase kinase

Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase

Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites

Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex

Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase

SWISS-MODEL: An automated protein homology-modeling server

Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications

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992-1004

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10.1016/J.STR.2007.07.001

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17683942

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protein kinase activity

dichloroacetate

Pyruvate dehydrogenase kinase 1

structural biology

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2871385

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