A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
about
Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complexRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinRibosome-based quality control of mRNA and nascent peptidesRibosome-associated protein quality controlThe 26S proteasome is a multifaceted target for anti-cancer therapiesRegulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin LigasesDNAJs: more than substrate delivery to HSPACdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products.Protein quality control systems associated with no-go and nonstop mRNA surveillance in yeast.The tRNA Splicing Endonuclease Complex Cleaves the Mitochondria-localized CBP1 mRNA.Asc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats.An inducible chaperone adapts proteasome assembly to stress.Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling.The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation.The Cdc48-Vms1 complex maintains 26S proteasome architecture.Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.Proteomics of protein post-translational modifications implicated in neurodegenerationPerilous journey: a tour of the ubiquitin-proteasome systemListerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociationRibosomal proteins produced in excess are degraded by the ubiquitin-proteasome systemInitiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome UbiquitinationZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal UbiquitylationStructural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution.Estimating Gene Expression and Codon-Specific Translational Efficiencies, Mutation Biases, and Selection Coefficients from Genomic Data AloneQuantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resourcesAsc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation.The ribosome-bound quality control complex remains associated to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregationNovel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.A highly conserved family of domains related to the DNA-glycosylase fold helps predict multiple novel pathways for RNA modificationsFission yeast mtr1p regulates interphase microtubule cortical dwell-timeThe VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factorsSequence selectivity of macrolide-induced translational attenuationThe biology of proteostasis in aging and disease.Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex.Mechanisms of In Vivo Ribosome Maintenance Change in Response to Nutrient Signals.
P2860
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P248
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P2860
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A ribosome-bound quality contr ...... and signals translation stress
@ast
A ribosome-bound quality contr ...... and signals translation stress
@en
A ribosome-bound quality contr ...... nd signals translation stress.
@nl
type
label
A ribosome-bound quality contr ...... and signals translation stress
@ast
A ribosome-bound quality contr ...... and signals translation stress
@en
A ribosome-bound quality contr ...... nd signals translation stress.
@nl
altLabel
A ribosome-bound quality contr ...... and signals translation stress
@en
prefLabel
A ribosome-bound quality contr ...... and signals translation stress
@ast
A ribosome-bound quality contr ...... and signals translation stress
@en
A ribosome-bound quality contr ...... nd signals translation stress.
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
A ribosome-bound quality contr ...... and signals translation stress
@en
P2093
Adam Frost
Adam Larson
Christopher C Williams
Daisy Wong
David King
Gene-Wei Li
Onn Brandman
Peter S Shen
Sharleen Zhou
Silvi Rouskin
P2860
P304
P3181
P356
10.1016/J.CELL.2012.10.044
P407
P577
2012-11-21T00:00:00Z