about
Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced ActivityProtein Folding and Mechanisms of ProteostasismTORC1 signaling activates NRF1 to increase cellular proteasome levelsInteraction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicityTmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response.Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in MelanomaCellular proteostasis: degradation of misfolded proteins by lysosomesDynamics, flexibility, and allostery in molecular chaperoninsTemsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular PhenotypeThe Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutationsImpaired protein stability and nuclear localization of NOBOX variants associated with premature ovarian insufficiencyBacterial proteostasis balances energy and chaperone utilization efficientlyThe burden of trisomy 21 disrupts the proteostasis network in Down syndrome.Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases.Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling.The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesEndoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to ImmunosenescenceDifferential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegansProtein homeostasis of a metastable subproteome associated with Alzheimer's disease.Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in miceGranulostasis: Protein Quality Control of RNP Granules.Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblastsRepression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction.Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.Prion-Associated Toxicity is Rescued by Elimination of Cotranslational Chaperones.Middle Age Has Its Advantages.Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging.A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans.Hallmarks of therapeutic management of the cystic fibrosis functional landscape.Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response.HSF1: Guardian of Proteostasis in CancerDesign and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid PolypeptideAneuploidy shortens replicative lifespan in Saccharomyces cerevisiaeA transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregationMorphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis.Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primatePathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response.Small heat shock proteins mediate cell-autonomous and -nonautonomous protection in a Drosophila model for environmental-stress-induced degeneration.E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մարտին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
The biology of proteostasis in aging and disease.
@ast
The biology of proteostasis in aging and disease.
@en
The biology of proteostasis in aging and disease.
@nl
type
label
The biology of proteostasis in aging and disease.
@ast
The biology of proteostasis in aging and disease.
@en
The biology of proteostasis in aging and disease.
@nl
prefLabel
The biology of proteostasis in aging and disease.
@ast
The biology of proteostasis in aging and disease.
@en
The biology of proteostasis in aging and disease.
@nl
P2860
P1476
The biology of proteostasis in aging and disease.
@en
P2093
Johnathan Labbadia
Richard I Morimoto
P2860
P304
P356
10.1146/ANNUREV-BIOCHEM-060614-033955
P577
2015-03-12T00:00:00Z