RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit.
about
Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory systemIdentification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1De novo origination of a new protein-coding gene in Saccharomyces cerevisiaeLarge-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathwaysChaperone-mediated pathway of proteasome regulatory particle assemblyIdentification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathwaysUse of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13Conservation and evolution of cis-regulatory systems in ascomycete fungiHDACs and the senescent phenotype of WI-38 cells.The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its deathStructure and function of the yeast U-box-containing ubiquitin ligase Ufd2pAn Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradationDual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assemblyMolecular architecture and assembly of the eukaryotic proteasomeStructure and properties of transcriptional networks driving selenite stress response in yeastsBlm10 binds to pre-activated proteasome core particles with open gate conformation.Inhibition of proteasomal degradation of rpn4 impairs nonhomologous end-joining repair of DNA double-strand breaks.Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation.The C-terminal extension of the beta7 subunit and activator complexes stabilize nascent 20 S proteasomes and promote their maturation.Mapping of yeast Rpn4p transactivation domains.Hexameric assembly of the proteasomal ATPases is templated through their C terminiPolyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizymeA Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasisRpn4 is a physiological substrate of the Ubr2 ubiquitin ligase.A stress regulatory network for co-ordinated activation of proteasome expression mediated by yeast heat shock transcription factor.An inducible chaperone adapts proteasome assembly to stress.Analysis of quality control substrates in distinct cellular compartments reveals a unique role for Rpn4p in tolerating misfolded membrane proteins.Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5.Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex.The Cdc48-Vms1 complex maintains 26S proteasome architecture.The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle.Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity.Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response.Yeast importin-α (Srp1) performs distinct roles in the import of nuclear proteins and in targeting proteasomes to the nucleus.A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathwayAn evolutionarily conserved pathway controls proteasome homeostasisLoss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegenerationMolecular architecture of the 26S proteasome holocomplex determined by an integrative approach
P2860
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P2860
RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@ast
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@en
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@nl
type
label
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@ast
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@en
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@nl
prefLabel
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@ast
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@en
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@nl
P2860
P3181
P356
P1476
RPN4 is a ligand, substrate, a ...... : a negative feedback circuit.
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.071022298
P407
P577
2001-03-13T00:00:00Z