Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration - Test2 - elhamkhani - TriplyDB

Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration

Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration

http://www.wikidata.org/entity/Q28236609

about

Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration.The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion Induction of Herpud1 expression by ER stress is regulated by Nrf1 The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1 Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition Transcription factor Nrf1 is negatively regulated by its O-GlcNAcylation status Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosis Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.Direct interaction between the WD40 repeat protein WDR-23 and SKN-1/Nrf inhibits binding to target DNA.NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes Regulating the 20S proteasome ubiquitin-independent degradation pathway.Concerted perturbation observed in a hub network in Alzheimer's disease Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domains Proteasome functional insufficiency in cardiac pathogenesis.Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system.Integrative analysis of haplotype-resolved epigenomes across human tissues.Changes in 20S subunit composition are largely responsible for altered proteasomal activities in experimental autoimmune encephalomyelitis.The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.Ubiquitin receptors and protein quality control The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity.Small Maf proteins (MafF, MafG, MafK): History, structure and function.Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution.A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways.Genome-wide analyses in neuronal cells reveal that upstream transcription factors regulate lysosomal gene expression.UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review.Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma.The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.

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Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration

http://www.wikidata.org/entity/Q28236609

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2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年论文

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Loss of nuclear factor E2-rela ...... pression and neurodegeneration

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Loss of nuclear factor E2-rela ...... pression and neurodegeneration

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Loss of nuclear factor E2-rela ...... pression and neurodegeneration

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Loss of nuclear factor E2-rela ...... pression and neurodegeneration

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Loss of nuclear factor E2-rela ...... pression and neurodegeneration

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Loss of nuclear factor E2-rela ...... pression and neurodegeneration

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Proceedings of the National Academy of Sciences of the United States of America

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Loss of nuclear factor E2-rela ...... pression and neurodegeneration

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Candy S Lee

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Chiashan Lee

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Eric J Huang

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Janice M Nguyen

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Jefferson Y Chan

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Jiasheng Zhang

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Terry Hu

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P2860

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast

Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

A gated channel into the proteasome core particle

Structure of 20S proteasome from yeast at 2.4 A resolution

Mechanisms underlying ubiquitination

The ubiquitin system

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit.

Nrf1 is critical for redox balance and survival of liver cells during development

Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

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21536885

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