The Prp19p-associated complex in spliceosome activation.
about
Cwc24p is a general Saccharomyces cerevisiae splicing factor required for the stable U2 snRNP binding to primary transcriptsA subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicingSNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assemblyComposition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexesMolecular architecture of the human Prp19/CDC5L complexThe RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complexCwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centreIsolation and characterization of post-splicing lariat-intron complexesPRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryTumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activityThe Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosomeThe N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA bindingEarly embryonic lethality of mice lacking the essential protein SNEVThe Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damageThe ASRG database: identification and survey of Arabidopsis thaliana genes involved in pre-mRNA splicingRoles of RNA-Binding Proteins in DNA Damage ResponseFunctional roles of DExD/H-box RNA helicases in Pre-mRNA splicingRPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseSplicing fidelity: DEAD/H-box ATPases as molecular clocksThe Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for Its FunctionStructure of the mRNA splicing complex component Cwc2: insights into RNA recognitionCrystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding proteinThe crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicingStructural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complexCryo-EM structure of the spliceosome immediately after branchingThe RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicingYeast ntr1/spp382 mediates prp43 function in postspliceosomes.A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicingSystematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing.Inhibition of a spliceosome turnover pathway suppresses splicing defects.The splicing ATPase prp43p is a component of multiple preribosomal particles.The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing.Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activationReconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components.Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2.Cwc24p, a novel Saccharomyces cerevisiae nuclear ring finger protein, affects pre-snoRNA U3 splicing.Ntc90 is required for recruiting first step factor Yju2 but not for spliceosome activation.MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome
P2860
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P2860
The Prp19p-associated complex in spliceosome activation.
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The Prp19p-associated complex in spliceosome activation.
@ast
The Prp19p-associated complex in spliceosome activation.
@en
The Prp19p-associated complex in spliceosome activation.
@nl
type
label
The Prp19p-associated complex in spliceosome activation.
@ast
The Prp19p-associated complex in spliceosome activation.
@en
The Prp19p-associated complex in spliceosome activation.
@nl
prefLabel
The Prp19p-associated complex in spliceosome activation.
@ast
The Prp19p-associated complex in spliceosome activation.
@en
The Prp19p-associated complex in spliceosome activation.
@nl
P2093
P3181
P356
P1433
P1476
The Prp19p-associated complex in spliceosome activation.
@en
P2093
Soo-Chen Cheng
Wei-Yü Tsai
P304
P3181
P356
10.1126/SCIENCE.1086602
P407
P577
2003-10-10T00:00:00Z