PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry
about
Functions of Ubiquitin and SUMO in DNA Replication and Replication StressATR-mediated regulation of nuclear and cellular plasticityRoles of RNA-Binding Proteins in DNA Damage ResponseThe RNA Splicing Response to DNA DamageRPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseReal-time imaging of DNA damage in yeast cells using ultra-short near-infrared pulsed laser irradiationUbiquitylation, neddylation and the DNA damage responseSystematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repairSUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathwayRFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life spanProtein dynamics during presynaptic-complex assembly on individual single-stranded DNA moleculesHERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stabilityQuantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana.The spliceosomal PRP19 complex of trypanosomesA Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription FactorsInteraction with Single-stranded DNA-binding Protein Stimulates Escherichia coli Ribonuclease HI Enzymatic Activity.SLFN11 inhibits checkpoint maintenance and homologous recombination repair.ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection.Role of the Exocyst Complex Component Sec6/8 in Genomic StabilityEwing Tumor-associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks.RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.PTEN regulates RPA1 and protects DNA replication forks.Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.DNA mismatch repair and the DNA damage response.The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugsSNEV(Prp19/PSO4) deficiency increases PUVA-induced senescence in mouse skinTetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombinationPrp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/twist1 pathway.BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis.The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR).Genome-wide DNA copy number analysis in clonally expanded human ovarian cancer cells with distinct invasive/migratory capacities.How gene expression in fast-proliferating cells keeps pace.The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability.hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes.The essential kinase ATR: ensuring faithful duplication of a challenging genome.
P2860
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P248
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P2860
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry
description
2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@ast
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@en
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@en-gb
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@nl
type
label
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@ast
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@en
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@en-gb
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@nl
prefLabel
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@ast
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@en
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@en-gb
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@nl
P2093
P2860
P3181
P1433
P1476
PRP19 transforms into a sensor ...... a ubiquitin-mediated circuitry
@en
P2093
Amanda E Jiménez
Hai Dang Nguyen
Jianping Jin
Shizhou Liu
Stephanie A Yazinski
Xiao Ye Ji
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2013.11.002
P407
P577
2013-12-12T00:00:00Z