The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome
about
Structural variability of the ubiquitin specific protease DUSP-UBL double domainsCTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradationThe RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complexPRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryThe U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitinationRoles of RNA-Binding Proteins in DNA Damage ResponseThe business of deubiquitination - location, location, locationRole of Deubiquitinating Enzymes in DNA RepairFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workRPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseThe Prp19 complex directly functions in mitotic spindle assemblyThe crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicingStructure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like DomainsSystematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.Efficient mRNA polyadenylation requires a ubiquitin-like domain, a zinc knuckle, and a RING finger domain, all contained in the Mpe1 protein.The role of UBL domains in ubiquitin-specific proteasesUSP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesisOverexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemiaEvolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genesEvolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cellsThe role of the human psoralen 4 (hPso4) protein complex in replication stress and homologous recombination.USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31.Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life spanPrp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptaseTip110 interacts with YB-1 and regulates each other's function.SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.Small kinetochore associated protein (SKAP) promotes UV-induced cell apoptosis through negatively regulating pre-mRNA processing factor 19 (Prp19).Ubiquitin and transcription: The SCF/Met4 pathway, a (protein-) complex issue.The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling.Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control.An Rtf2 Domain-Containing Protein Influences Pre-mRNA Splicing and Is Essential for Embryonic Development in Arabidopsis thaliana.Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation.The spliceosome-activating complex: molecular mechanisms underlying the function of a pleiotropic regulatorFunctional roles of protein splicing factors.A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.Spliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!Link of NTR-mediated spliceosome disassembly with DEAH-box ATPases Prp2, Prp16, and Prp22.The Colossus of ubiquitylation: decrypting a cellular code.
P2860
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P248
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P2860
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@ast
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@en
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@en-gb
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@nl
type
label
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@ast
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@en
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@en-gb
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@nl
prefLabel
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@ast
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@en
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@en-gb
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@nl
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
The Prp19 complex and the Usp4 ...... quitination at the spliceosome
@en
P2093
Donald Rio
Eun Joo Song
Frank Stegmeier
J Wade Harper
Jakob Neubauer
Marc W Kirschner
Shannon L Werner
P2860
P304
P3181
P356
10.1101/GAD.1925010
P407
P577
2010-07-01T00:00:00Z