C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
about
The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation.CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the ciliumNovel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartmentUpdate on oral-facial-digital syndromes (OFDS)A primer on the mouse basal bodyHuman basal body basicsSAS-1 is a C2 domain protein critical for centriole integrity in C. elegansC2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transductionPCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tubeCoordinated translocation of mammalian Gli proteins and suppressor of fused to the primary ciliumCep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2.Analysis of hedgehog signaling in mouse intraflagellar transport mutantsClinical implications of hedgehog signaling pathway inhibitorsUsing the avian mutant talpid2 as a disease model for understanding the oral-facial phenotypes of oral-facial-digital syndromeThe Hedgehog pathway: role in cell differentiation, polarity and proliferationGenetic link between renal birth defects and congenital heart diseaseThe relationship between sonic Hedgehog signaling, cilia, and neural tube defectsMutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 functionUtilizing the chicken as an animal model for human craniofacial ciliopathies.Targeting hedgehog signaling in cancer: research and clinical developments.Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia.Understanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid2.Mutations in the Motile Cilia Gene DNAAF1 Are Associated with Neural Tube Defects in Humans.Activation of the hedgehog-signaling pathway in human cancer and the clinical implications.The primary cilium as a Hedgehog signal transduction machine.Hedgehog signaling in skin cancersPrimary cilia and graded Sonic Hedgehog signaling.Unmasking the ciliopathies: craniofacial defects and the primary cilium.Mutations in ARMC9, which Encodes a Basal Body Protein, Cause Joubert Syndrome in Humans and Ciliopathy Phenotypes in Zebrafish.Discovery, Diagnosis, and Etiology of Craniofacial Ciliopathies.Primary Cilia and Mammalian Hedgehog Signaling.An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.Mutations in C2CD3 cause oral-facial-digital syndrome through deregulation of centriole length.Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of ciliaWDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.C2CD3 binds the mother centrioleSending mixed signals: Cilia-dependent signaling during development and disease.Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome.
P2860
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P248
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P2860
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
@ast
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
@en
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
@nl
type
label
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
@ast
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
@en
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
@nl
altLabel
C2cd3 is required for cilia formation and Hedgehog signaling in mouse
@en
prefLabel
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
@ast
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
@en
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
@nl
P2093
P2860
P921
P3181
P356
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P1476
C2cd3 is required for cilia formation and Hedgehog signaling in mouse
@en
P2093
Aaron Wynkoop
Huiqing Zeng
Jinping Jia
P2860
P304
P3181
P356
10.1242/DEV.029835
P407
P577
2008-11-12T00:00:00Z