Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy
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HSPB1 facilitates the formation of non-centrosomal microtubulesChaperonopathies: Spotlight on Hereditary Motor NeuropathiesCharcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilamentsCharacterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron DiseasesAxonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel MutationsCataract-causing αAG98R-crystallin mutant dissociates into monomers having chaperone activity.The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in TaiwanOn the effect of protein conformation diversity in discriminating among neutral and disease related single amino acid substitutions.TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association.A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosisSchizophrenia-Associated MIR204 Regulates Noncoding RNAs and Affects Neurotransmitter and Ion Channel Gene Sets.Truncated HSPB1 causes axonal neuropathy and impairs tolerance to unfolded protein stress.Structural and functional aspects of hetero-oligomers formed by the small heat shock proteins αB-crystallin and HSP27Recent advances in the genetics of hereditary axonal sensory-motor neuropathies type 2.Large potentials of small heat shock proteins.Animal models and therapeutic prospects for Charcot-Marie-Tooth disease.Neurofilament dynamics and involvement in neurological disorders.HSPB1 mutations causing hereditary neuropathy in humans disrupt non-cell autonomous protection of motor neurons.MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets.Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative diseaseMicrotubule dynamics in the peripheral nervous system: A matter of balance.HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis.Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1.pH-dependent structural modulation is conserved in the human small heat shock protein HSBP1.Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases.Characterization of New Transgenic Mouse Models for Two Charcot-Marie-Tooth-Causing HspB1 Mutations using the Rosa26 Locus.Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease.Oligomeric structure and chaperone-like activity of Drosophila melanogaster mitochondrial small heat shock protein Hsp22 and arginine mutants in the alpha-crystallin domain.Chaperone activity of human small heat shock protein-GST fusion proteins.Oligomerization and chaperone-like activity of Drosophila melanogaster small heat shock protein DmHsp27 and three arginine mutants in the alpha-crystallin domain.eIF4E Phosphorylation in Prostate Cancer.
P2860
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P2860
Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy
description
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2010
@ast
im April 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/04/23)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/04/23)
@nl
наукова стаття, опублікована у квітні 2010
@uk
name
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@ast
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@en
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@nl
type
label
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@ast
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@en
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@nl
prefLabel
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@ast
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@en
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@nl
P2093
P2860
P50
P3181
P356
P1476
Increased monomerization of mu ...... Charcot-Marie-Tooth neuropathy
@en
P2093
Frederic Rousseau
Joost Van Durme
Sofie Goethals
Sophie Janssens
Vicky de Winter
P2860
P304
12778–12786
P3181
P356
10.1074/JBC.M109.082644
P407
P50
P577
2010-04-23T00:00:00Z