The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
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Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the SpotRecent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1DNA Damage Response and Autophagy: A Meaningful PartnershipThe GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome FunctionThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingThe Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle.Amino acid homeostasis and signalling in mammalian cells and organisms.From Krebs to clinic: glutamine metabolism to cancer therapy.Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy.Mechanism of arginine sensing by CASTOR1 upstream of mTORC1Architecture of the human interactome defines protein communities and disease networks.Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease.Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.The lysosome as a command-and-control center for cellular metabolism.Regulation and function of the SLC38A3/SNAT3 glutamine transporter.Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency.Unsolved mysteries of Rag GTPase signaling in yeast.A molecular and neuronal basis for amino acid sensing in the Drosophila larva.Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathwaymTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress.Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer.Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism.Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.mTOR Signaling in Growth, Metabolism, and Disease.Comparison of the general co-expression landscapes between human and mouse.Amino Acid Sensing in Skeletal Muscle.T-cell metabolism governing activation, proliferation and differentiation; a modular view.Long non-coding RNAs in cancer metabolism.Recent advances in targeting mTOR signaling pathway using small molecule inhibitors.Nutrients and the microenvironment to feed a T cell army.Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.Arginine Metabolism Revisited.Leucine and Mammalian Target of Rapamycin-Dependent Activation of Muscle Protein Synthesis in Aging.Life history evolution, reproduction, and the origins of sex-dependent aging and longevity.Autophagy in the liver: functions in health and disease.Nutrient sensing and TOR signaling in yeast and mammals.Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment.mTORC1 senses stresses: Coupling stress to proteostasis.
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P2860
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
description
2016 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2016
@ast
im März 2016 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
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vedecký článok (publikovaný 2016/03/24)
@sk
vědecký článek publikovaný v roce 2016
@cs
wetenschappelijk artikel (gepubliceerd op 2016/03/24)
@nl
наукова стаття, опублікована в березні 2016
@uk
مقالة علمية (نشرت في 24-3-2016)
@ar
name
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@ast
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@en
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@nl
type
label
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@ast
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@en
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@nl
prefLabel
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@ast
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@en
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@nl
P2093
P2860
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The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
@en
P2093
David M. Sabatini
Gregory A. Wyant
J. Wade Harper
Kuang Shen
Lynne Chantranupong
Melanie P. Gygi
Robert A. Saxton
Sonia M. Scaria
P2860
P304
P3181
P356
10.1016/J.CELL.2016.02.035
P407
P577
2016-03-24T00:00:00Z