The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
about
PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growthTBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1Germline mutations in TMEM127 confer susceptibility to pheochromocytomaSecond AKT: the rise of SGK in cancer signallingPostnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmissionRagulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acidsRab1A is an mTORC1 activator and a colorectal oncogeneSLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal functionMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic stateControl of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinaseSH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signalingGlucocerebrosidase is shaking up the synucleinopathiesRegulation of TOR by small GTPasesRapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevityProtein kinases and phosphatases in the control of cell fateRole of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacksSpatial regulation of the mTORC1 system in amino acids sensing pathwayDiscovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancerCholesterol trafficking is required for mTOR activation in endothelial cellsPushing the envelope in the mTOR pathway: the second generation of inhibitorsAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyMammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyState of the science: an update on renal cell carcinomaFoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and RictorTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapymTOR: from growth signal integration to cancer, diabetes and ageingmTOR signaling in growth control and diseaseCharacterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylationAtf4 regulates obesity, glucose homeostasis, and energy expenditureSystems biology: On the cell cycle and its switchesCommon mechanisms of PIKK regulationAdapting the Stress Response: Viral Subversion of the mTOR Signaling PathwayChronic over-nutrition and dysregulation of GSK3 in diseasesAutophagy in Chronic Kidney DiseasesThe role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
P2860
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P2860
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@ast
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@en
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@en-gb
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@nl
type
label
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@ast
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@en
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@en-gb
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@nl
prefLabel
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@ast
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@en
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@en-gb
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
@en
P2093
Carson C Thoreen
Liron Bar-Peled
Robert A Lindquist
Timothy R Peterson
Yasemin Sancak
Yoav D Shaul
P2860
P304
P3181
P356
10.1126/SCIENCE.1157535
P407
P5008
P577
2008-05-22T00:00:00Z