BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
about
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4aExome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinomaTwo related ARID family proteins are alternative subunits of human SWI/SNF complexesAmplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinomaHLTF gene silencing in human colon cancer.Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancerMicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and agingmSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cadNovel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partnerMammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomicsGEMMs as preclinical models for testing pancreatic cancer therapiesATP-dependent chromatin remodeling complexes as novel targets for cancer therapyEmerging patterns of somatic mutations in cancerEpigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancerBrg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestineBRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51.SMARCA4/BRG1 Is a Novel Prognostic Biomarker Predictive of Cisplatin-Based Chemotherapy Outcomes in Resected Non-Small Cell Lung CancerTranscription activator interactions with multiple SWI/SNF subunits.A conserved Swi2/Snf2 ATPase motif couples ATP hydrolysis to chromatin remodelingThe tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancerA Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid developmentDisruption of Ini1 leads to peri-implantation lethality and tumorigenesis in micePhysical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cellsGermline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome.Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanismHuman T-lymphotropic virus type 1 transcription and chromatin-remodeling complexes.Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis.BRG1 promotes hepatocarcinogenesis by regulating proliferation and invasivenessBAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancerThe BRG1- and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene.Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescenceBrg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1.Whole genome expression profiling shows that BRG1 transcriptionally regulates UV inducible genes and other novel targets in human cellsFlavonoids from each of the six structural groups reactivate BRM, a possible cofactor for the anticancer effects of flavonoidsProteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists.Epigenetics of prostate cancer: beyond DNA methylationCooperative activity of BRG1 and Z-DNA formation in chromatin remodeling.SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.
P2860
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P2860
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
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2000 nî lūn-bûn
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BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
@ast
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
@en
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
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label
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
@ast
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
@en
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
@nl
prefLabel
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
@ast
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
@en
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
@nl
P2093
P3181
P1433
P1476
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
@en
P2093
A M Woodland
B Swedlund
F Shanahan
P304
P3181
P407
P577
2000-11-01T00:00:00Z