MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway
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ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activationAn analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitroErk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defectsErk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signalingRole of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cellsKnockout of ERK5 causes multiple defects in placental and embryonic developmentMEK5/ERK5 pathway: the first fifteen yearsIdentification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agentsERK5 Mediated Signalling in Diabetic RetinopathyERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformationIdentification and characterization of a novel MAP kinase kinase kinase, MLTKInteraction codes within the family of mammalian Phox and Bem1p domain-containing proteinsWNK1 activates ERK5 by an MEKK2/3-dependent mechanismMEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulationWNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertensionTargeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathwayRole of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5ERK7 is an autoactivated member of the MAPK familyERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expressionBMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction.Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival.A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity.MEK and the inhibitors: from bench to bedside.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors.Modulation of protein kinase signaling cascades by palytoxin.MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via SrcMEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cellsNew insights into the biogenesis of nuclear RNA polymerases?Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart TransplantationTGFβ2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasionThe cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.Pharmacology and anti-tumor activity of RWJ67657, a novel inhibitor of p38 mitogen activated protein kinaseMAPK signalling: ERK5 versus ERK1/2.Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signalingRegulation of MAPKs by growth factors and receptor tyrosine kinasesCerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.Nuclear factor-kappa B activation by the CXC chemokine melanoma growth-stimulatory activity/growth-regulated protein involves the MEKK1/p38 mitogen-activated protein kinase pathway
P2860
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P2860
MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@ast
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@en
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@nl
type
label
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@ast
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@en
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@nl
prefLabel
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@ast
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@en
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@nl
P2093
P2860
P3181
P356
P1476
MEKK3 directly regulates MEK5 ...... ase 1 (BMK1) signaling pathway
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.274.51.36035
P407
P577
1999-12-17T00:00:00Z