Catalytic promiscuity and the evolution of new enzymatic activities
about
Evolution of minimal specificity and promiscuity in steroid hormone receptorsIn the light of directed evolution: pathways of adaptive protein evolutionHow drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionFundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesA genomic overview of pyridoxal-phosphate-dependent enzymesCharacterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii.Biochemical conservation and evolution of germacrene A oxidase in asteraceaeHigh-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallographyBiological phosphoryl-transfer reactions: understanding mechanism and catalysisQuantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthasesAlkaline phosphatase mono- and diesterase reactions: comparative transition state analysisMechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticityDifferential substrate specificity and kinetic behavior of Escherichia coli YfdW and Oxalobacter formigenes formyl coenzyme A transferaseOhno's dilemma: evolution of new genes under continuous selectionCan sequence determine function?Catalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosLThe role of robustness in phenotypic adaptation and innovationUltrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.Structural Basis for Dual Functionality of Isoflavonoid O-Methyltransferases in the Evolution of Plant Defense ResponsesMimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activityStructure and mechanism of a bacterial haloalcohol dehalogenase: a new variation of the short-chain dehydrogenase/reductase fold without an NAD(P)H binding siteDiscovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography †Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenaxComparative Enzymology in the Alkaline Phosphatase Superfamily to Determine the Catalytic Role of an Active-Site Metal IonThe Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding FunctionsAn efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamilyIdentification of promiscuous ene-reductase activity by mining structural databases using active site constellationsBiochemical and Structural Studies of 6-Carboxy-5,6,7,8-tetrahydropterin Synthase Reveal the Molecular Basis of Catalytic Promiscuity within the Tunnel-fold SuperfamilyMINEs: open access databases of computationally predicted enzyme promiscuity products for untargeted metabolomicsExploitation of latent allostery enables the evolution of new modes of MAP kinase regulationThe Generation and Exploitation of Protein Mutability Landscapes for Enzyme EngineeringMulticopy suppression underpins metabolic evolvabilityMetabolite damage and its repair or pre-emptionThe 'evolvability' of promiscuous protein functionsParaoxonases as potential antibiofilm agents: their relationship with quorum-sensing signals in Gram-negative bacteriaCatalytic and binding poly-reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolutionThe evolution of enzyme specificity in the metabolic replicator model of prebiotic evolutionCollective dynamics differentiates functional divergence in protein evolutionOccurrence of a putative ancient-like isomerase involved in histidine and tryptophan biosynthesisEndogenous stress caused by faulty oxidation reactions fosters evolution of 2,4-dinitrotoluene-degrading bacteria
P2860
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P2860
Catalytic promiscuity and the evolution of new enzymatic activities
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Catalytic promiscuity and the evolution of new enzymatic activities
@ast
Catalytic promiscuity and the evolution of new enzymatic activities
@en
Catalytic promiscuity and the evolution of new enzymatic activities
@nl
type
label
Catalytic promiscuity and the evolution of new enzymatic activities
@ast
Catalytic promiscuity and the evolution of new enzymatic activities
@en
Catalytic promiscuity and the evolution of new enzymatic activities
@nl
prefLabel
Catalytic promiscuity and the evolution of new enzymatic activities
@ast
Catalytic promiscuity and the evolution of new enzymatic activities
@en
Catalytic promiscuity and the evolution of new enzymatic activities
@nl
P3181
P1476
Catalytic promiscuity and the evolution of new enzymatic activities
@en
P2093
D Herschlag
P J O'Brien
P304
P3181
P356
10.1016/S1074-5521(99)80033-7
P407
P577
1999-04-01T00:00:00Z