NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
about
MDC1 is a mediator of the mammalian DNA damage checkpointMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionAcetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitroPhosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domainsMDC1 is required for the intra-S-phase DNA damage checkpointNFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage responseNFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathwaysNFBD1/MDC1 is a protein of oncogenic potential in human cervical cancerThe DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosomeNFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damageNFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpointMDC1 functionally identified as an androgen receptor co-activator participates in suppression of prostate cancer.Checking on DNA damage in S phase.Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition.p53: the attractive tumor suppressor in the cancer research field.Role of p53 in Cell Death and Human Cancers.Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells.NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53.Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation.NFBD1/MDC1 participates in the regulation of proliferation and apoptosis in human laryngeal squamous cell carcinoma.Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants.
P2860
Q24296229-0D8788DD-2331-4D09-A29F-626FE7088C98Q24563397-4321574D-CDEC-4D17-B3EA-F57CD8864E8EQ27303150-89341DB7-E027-490E-B110-0D150E6BE532Q28212425-198AFBB8-16F8-4528-98F8-2329E0C12F5CQ28212500-75344E6A-D3A8-4BF1-A93F-421445054BA9Q28217141-7660C5F0-D3EB-4E46-B38A-E04192622752Q28218966-01FF389D-215D-4DAB-B939-92CA94ED37E4Q28245966-361EADF5-5B7F-4FCF-B498-47DAC624B5DAQ28247374-FE79981A-CBAB-41E6-B9AA-92905E58E443Q28304255-865E240D-6473-496B-9AE7-6D8EE46A5F09Q35070481-280CAFF9-9152-4A5E-8A66-AC1A468AD6D4Q35656832-15CA76D3-D677-44C1-B28C-8FF176E8FDF7Q35906070-6CEC0A03-5203-4465-B9E7-1C970F142024Q36022277-2240CC02-3130-4E8B-B61F-262A436FF231Q37824262-F20EEADE-67F7-4234-946A-D5DB75875ECCQ38161342-5F5689B0-455E-4040-A209-5C14BA7E2EB5Q38762742-20A8837D-2BF7-4E85-9A92-775488AFCDD7Q39546495-FCEEBE19-5653-486A-8EA3-48FCEE4AFE47Q39945678-C6B129F4-72B0-4F93-A0FA-329781D600A4Q47786675-56CC7846-203F-4400-BF67-0B9093B496F9Q51064072-AFE4FFB1-824A-4CE4-B952-D8DA684DFCE8
P2860
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@ast
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@en
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@nl
type
label
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@ast
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@en
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@nl
prefLabel
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@ast
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@en
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@nl
P2093
P1433
P1476
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain
@en
P2093
A Nakagawara
S Ichimiya
S Sakiyama
P304
P356
10.1089/10445490050128403
P407
P577
2000-08-01T00:00:00Z