Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention - Test2 - elhamkhani - TriplyDB

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

http://www.wikidata.org/entity/Q24563397

about

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage Multiple roles of ATM in monitoring and maintaining DNA integrity Epigenetic modifications in double-strand break DNA damage signaling and repair MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation DNA End Resection: Facts and Mechanisms Chromatin perturbations during the DNA damage response in higher eukaryotes Beyond DNA repair: DNA-PK function in cancer DNA damage response and prostate cancer: defects, regulation and therapeutic implications Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells DNA DSB repair pathway choice: an orchestrated handover mechanism The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes Structure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage Sites The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator Pch2 acts through Xrs2 and Tel1/ATM to modulate interhomolog bias and checkpoint function during meiosis A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome MDC1 regulates DNA-PK autophosphorylation in response to DNA damage Cell-cycle checkpoints and cancer Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis Giraffe genome sequence reveals clues to its unique morphology and physiology.ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection.A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint.Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.Analysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation.Autophosphorylation and ATM activation: additional sites add to the complexity.Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

http://www.wikidata.org/entity/Q24563397

description

2004 nî lūn-bûn

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2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հուլիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年学术文章

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2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

name

Mdc1 couples DNA double-strand ...... -dependent chromatin retention

@ast

Mdc1 couples DNA double-strand ...... -dependent chromatin retention

@en

Mdc1 couples DNA double-strand ...... -dependent chromatin retention

@nl

type

label

Mdc1 couples DNA double-strand ...... -dependent chromatin retention

@ast

Mdc1 couples DNA double-strand ...... -dependent chromatin retention

@en

Mdc1 couples DNA double-strand ...... -dependent chromatin retention

@nl

prefLabel

Mdc1 couples DNA double-strand ...... -dependent chromatin retention

@ast

Mdc1 couples DNA double-strand ...... -dependent chromatin retention

@en

Mdc1 couples DNA double-strand ...... -dependent chromatin retention

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SJ.EMBOJ.7600269

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The EMBO Journal

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Mdc1 couples DNA double-strand ...... -dependent chromatin retention

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Fredrik Melander

http://www.w3.org/2001/XMLSchema#string

Jacob Falck

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Manuel Stucki

http://www.w3.org/2001/XMLSchema#string

Michal Goldberg

http://www.w3.org/2001/XMLSchema#string

Yaniv Lerenthal

http://www.w3.org/2001/XMLSchema#string

P2860

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

MDC1 is a mediator of the mammalian DNA damage checkpoint

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

Megabase chromatin domains involved in DNA double-strand breaks in vivo

A system for stable expression of short interfering RNAs in mammalian cells

Substrate specificities and identification of putative substrates of ATM kinase family members

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10.1038/SJ.EMBOJ.7600269

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13

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23

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Simon Bekker-Jensen

Stephen P Jackson

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2004-07-07T00:00:00Z

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8505586

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15201865

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449779

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