Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
about
GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposinThe protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell deathAlpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicityParkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer modelBiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of ParkinParkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1How does parkin ligate ubiquitin to Parkinson's disease?Molecules that cause or prevent Parkinson's diseaseParkin counteracts symptoms in a Drosophila model of Parkinson's disease.Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1Parkinson's disease: gene therapiesMolecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunctionThe protective role of prosaposin and its receptors in the nervous systemCell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animalsNebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signalingL166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome systemSuppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stressParkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathyPruning and loss of excitatory synapses by the parkin ubiquitin ligaseAltered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptorParkin promotes degradation of the mitochondrial pro-apoptotic ARTS proteinThe PINK1/Parkin pathway regulates mitochondrial morphologyMitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by ParkinGPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.Differential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS.Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.Effects of gender on nigral gene expression and parkinson disease.Role of the ubiquitin proteasome system in Parkinson's disease.Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's diseaseBacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors.Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.Drosophila models of neurodegenerative diseaseParkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionGenetic factors and manganese-induced neurotoxicity.Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling.
P2860
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P2860
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@ast
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@en
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@nl
type
label
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@ast
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@en
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@nl
prefLabel
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@ast
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@en
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@nl
P2093
P921
P1433
P1476
Parkin suppresses dopaminergic ...... nduced by Pael-R in Drosophila
@en
P2093
Bingwei Lu
Isao Nishimura
Ryosuke Takahashi
Yufeng Yang
Yuzuru Imai
P304
P356
10.1016/S0896-6273(03)00143-0
P407
P577
2003-03-27T00:00:00Z