Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1) - Test2 - elhamkhani - TriplyDB

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

http://www.wikidata.org/entity/Q24307730

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The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment Emerging modes of PINK1 signaling: another task for MARK2 PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1 E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia Oxidative stress and regulation of Pink1 in zebrafish (Danio rerio)Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.Parkinson's disease: insights from pathways.PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy Differential submitochondrial localization of PINK1 as a molecular switch for mediating distinct mitochondrial signaling pathways.Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease.PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR.Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?PINK1 function in health and disease Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis.Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1).Mitochondrial dynamics: the intersection of form and function.Oxidative stress in genetic mouse models of Parkinson's disease.Parkinson's disease: from genetics to treatments.Perturbed mitochondrial Ca2+ signals as causes or consequences of mitophagy induction.PINK1 Deficiency Decreases Expression Levels of mir-326, mir-330, and mir-3099 during Brain Development and Neural Stem Cell Differentiation.Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation.The mitochondrial kinase PINK1: functions beyond mitophagy.PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway.Impairment of oxidative stress-induced heme oxygenase-1 expression by the defect of Parkinson-related gene of PINK1.A Novel Homozygous p.L539F Mutation Identified in PINK1 Gene in a Moroccan Patient with Parkinsonism The Parkinson's disease-associated protein DJ-1 plays a positive nonmitochondrial role in endocytosis in Dictyostelium cells.PINK1 regulates mitochondrial trafficking in dendrites of cortical neurons through mitochondrial PKA.Subtle alterations of excitatory transmission are linked to presynaptic changes in the hippocampus of PINK1-deficient mice.

P2860

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P2860

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

http://www.wikidata.org/entity/Q24307730

description

2008 nî lūn-bûn

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2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2008 թվականի ապրիլին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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name

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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J.1471-4159.2008.05249.X

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Journal of Neurochemistry

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Chou Hung Sim

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Janetta G Culvenor

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Ryan D Mills

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Su San Mok

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P2860

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

PINK1 protein in normal human brain and Parkinson's disease

Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36

Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase

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10.1111/J.1471-4159.2008.05249.X

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1

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105

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Heung-Chin Cheng

Terrence D. Mulhern

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2008-04-01T00:00:00Z

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5631186

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18221368

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negative regulation of neuron death

HtrA serine peptidase 2

PTEN induced kinase 1

AKT serine/threonine kinase 1

TNF receptor associated protein 1

Mitogen-activated protein kinase 12

Parkin RBR E3 ubiquitin protein ligase

Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

TNF receptor associated factor 2