Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells - Test2 - elhamkhani - TriplyDB

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

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Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis Aurora A's Functions During Mitotic Exit: The Guess Who Game Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1 Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B.Essential role for a novel population of binucleated mammary epithelial cells in lactation.Two TPX2-dependent switches control the activity of Aurora A Context-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase Inhibitor The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment Aurora kinase-A deficiency during skin development impairs cell division and stratification Multiple cancer testis antigens function to support tumor cell mitotic fidelity.Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization.MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.A role for IkappaB kinase 2 in bipolar spindle assembly.Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG Aurora A kinase and its substrate TACC3 are required for central spindle assembly Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway GSK-3 inhibitors induce chromosome instability.Phase I study of MLN8237--investigational Aurora A kinase inhibitor--in relapsed/refractory multiple myeloma, non-Hodgkin lymphoma and chronic lymphocytic leukemia.Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.Aurora kinase inhibitors--rising stars in cancer therapeutics?Aurora kinase A is not involved in CPEB1 phosphorylation and cyclin B1 mRNA polyadenylation during meiotic maturation of porcine oocytes Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts.Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E.Recognizing and exploiting differences between RNAi and small-molecule inhibitors.The aurora kinases in cell cycle and leukemia The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy Aurora A kinase modulates actin cytoskeleton through phosphorylation of Cofilin: Implication in the mitotic process.Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus Significance estimation for sequence-based chemical similarity searching (PhAST) and application to AuroraA kinase inhibitors.Investigational Aurora A kinase inhibitor alisertib (MLN8237) as an enteric-coated tablet formulation in non-hematologic malignancies: phase 1 dose-escalation study.

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Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

http://www.wikidata.org/entity/Q28206475

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2003 nî lūn-bûn

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2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

@zh-hk

2003年論文

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2003年論文

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2003年论文

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name

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@ast

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@en

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@nl

type

label

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@ast

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@en

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@nl

prefLabel

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@ast

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@en

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

@en

P2093

Eiji Kohmura

http://www.w3.org/2001/XMLSchema#string

Hideyuki Saya

http://www.w3.org/2001/XMLSchema#string

Masayuki Nitta

http://www.w3.org/2001/XMLSchema#string

Shinobu Honda

http://www.w3.org/2001/XMLSchema#string

Tomotoshi Marumoto

http://www.w3.org/2001/XMLSchema#string

Toru Hirota

http://www.w3.org/2001/XMLSchema#string

Toshihiro Hara

http://www.w3.org/2001/XMLSchema#string

P2860

Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization

Human TPX2 is required for targeting Aurora-A kinase to the spindle

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

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51786-95

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scholarly article

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475769

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10.1074/JBC.M306275200

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P433

51

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P478

278

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2003-12-19T00:00:00Z

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P698

14523000

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