MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy. - Test2 - elhamkhani - TriplyDB

MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.

MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.

http://www.wikidata.org/entity/Q30479689

about

Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest Recent advances in the development of Aurora kinases inhibitors in hematological malignancies Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A Review Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes A Cell Biologist's Field Guide to Aurora Kinase Inhibitors NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells Aurora-A kinase is essential for bipolar spindle formation and early development Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis Inhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cells Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2 The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.Benzo[e]pyridoindoles, novel inhibitors of the aurora kinases.Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.Aurora kinase inhibitors--rising stars in cancer therapeutics?Finding the middle ground: how kinetochores power chromosome congression.Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.SERS and MD simulation studies of a kinase inhibitor demonstrate the emergence of a potential drug discovery tool Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E.Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells The aurora kinases in cell cycle and leukemia Golgi partitioning controls mitotic entry through Aurora-A kinase.Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors.Update on aurora kinase inhibitors in gynecologic malignancies.Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules.Update on Aurora Kinase Targeted Therapeutics in Oncology.Generation and characterization of novel monoclonal antibodies against human aurora-A.The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.Mitotic entry: Non-genetic heterogeneity exposes the requirement for Plk1.Aurora kinase inhibitors as anticancer molecules.Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma.Cell death signaling and anticancer therapy Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism.Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo.

P2860

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P2860

MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.

http://www.wikidata.org/entity/Q30479689

description

2007 nî lūn-bûn

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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2007 թվականի ապրիլին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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MLN8054, a small-molecule inhi ...... defects leading to aneuploidy.

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MLN8054, a small-molecule inhi ...... defects leading to aneuploidy.

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MLN8054, a small-molecule inhi ...... defects leading to aneuploidy.

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MLN8054, a small-molecule inhi ...... defects leading to aneuploidy.

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MLN8054, a small-molecule inhi ...... defects leading to aneuploidy.

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MLN8054, a small-molecule inhi ...... defects leading to aneuploidy.

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Molecular and Cellular Biology

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MLN8054, a small-molecule inhi ...... defects leading to aneuploidy.

@en

P2093

Arijit Chakravarty

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Claudia Rabino

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Deborah Wysong

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Douglas Bowman

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Jeffrey A Ecsedy

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Kara Hoar

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Natalie Roy

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P2860

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

The kinesin-like protein KLP61F is essential for mitosis in Drosophila

The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function

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4513-4525

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scholarly article

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10.1128/MCB.02364-06

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12

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27

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2007-04-16T00:00:00Z

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6390697

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17438137

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1900054

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