Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors
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Alternatively spliced isoforms of the human constitutive androstane receptorEvolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding geneUp-regulating CYP3A4 expression in C3A cells by transfection with a novel chimeric regulator of hPXR-p53-ADMolecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.Evolutionary history and functional characterization of the amphibian xenosensor CAR.CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands.Identification of the xenosensors regulating human 5-aminolevulinate synthasePredicting inductive drug-drug interactions.Drug-activated nuclear receptors CAR and PXR.Small-molecule modulators of the constitutive androstane receptor.RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignanciesPXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.Signaling control of the constitutive androstane receptor (CAR)Quantitative High-Throughput Luciferase Screening in Identifying CAR Modulators.Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.Regulation of gene expression by CAR: an update.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear factor 4, PBX-PREP1, the thyroid hormone receptor beta and the liver X receptor.Amino acids important for ligand specificity of the human constitutive androstane receptor.Dual action of oestrogens on the mouse constitutive androstane receptor.Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons.Regulation of the human cathepsin E gene by the constitutive androstane receptorHepaRG culture in tethered spheroids as an in vitro three-dimensional model for drug safety screening.Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs.Detecting ligands and dissecting nuclear receptor-signaling pathways using recombinant strains of the yeast Saccharomyces cerevisiae.In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.
P2860
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P2860
Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Modulation of mouse and human ...... er module by nuclear receptors
@ast
Modulation of mouse and human ...... er module by nuclear receptors
@en
Modulation of mouse and human ...... er module by nuclear receptors
@nl
type
label
Modulation of mouse and human ...... er module by nuclear receptors
@ast
Modulation of mouse and human ...... er module by nuclear receptors
@en
Modulation of mouse and human ...... er module by nuclear receptors
@nl
prefLabel
Modulation of mouse and human ...... er module by nuclear receptors
@ast
Modulation of mouse and human ...... er module by nuclear receptors
@en
Modulation of mouse and human ...... er module by nuclear receptors
@nl
P2093
P356
P1476
Modulation of mouse and human ...... er module by nuclear receptors
@en
P2093
Carsten Carlberg
Christian Frank
Janne Mäkinen
Johanna Jyrkkärinne
Jukka Gynther
Paavo Honkakoski
P304
P356
10.1124/MOL.62.2.366
P407
P577
2002-08-01T00:00:00Z