about
Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptorThe evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammalsInsights into CYP2B6-mediated drug-drug interactionsNon-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 miceIdentification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transportA single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Activation of xenobiotic receptors: driving into the nucleus.Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver.Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes.Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alphaRegulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CARBiomonitoring of non-dioxin-like polychlorinated biphenyls in transgenic Arabidopsis using the mammalian pregnane X receptor system: a role of pectin in pollutant uptakeIdentification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.Transcriptional Regulation of CYP3A4/2B6/2C9 Mediated via Nuclear Receptor PXR by Helicid and Its MetabolitesThe orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor.Mode of action: neurotoxicity induced by thyroid hormone disruption during development--hearing loss resulting from exposure to PHAHs.Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liverIdentification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches.Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations.Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation.Nuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR activators in human primary hepatocytes.Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinicalRifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicityOxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands.Psychophysiological stress: a significant parameter in drug pharmacokinetics.Impact of Drug Treatment at Neonatal Ages on Variability of Drug Metabolism and Drug-drug Interactions in Adult Life.Gene expression profiling reveals potential key pathways involved in pyrazinamide-mediated hepatotoxicity in Wistar rats.Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner.Amino acids important for ligand specificity of the human constitutive androstane receptor.Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes.Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
name
Drug-activated nuclear receptors CAR and PXR.
@ast
Drug-activated nuclear receptors CAR and PXR.
@en
type
label
Drug-activated nuclear receptors CAR and PXR.
@ast
Drug-activated nuclear receptors CAR and PXR.
@en
prefLabel
Drug-activated nuclear receptors CAR and PXR.
@ast
Drug-activated nuclear receptors CAR and PXR.
@en
P2093
P2860
P1433
P1476
Drug-activated nuclear receptors CAR and PXR.
@en
P2093
Masahiko Negishi
Paavo Honkakoski
Tatsuya Sueyoshi
P2860
P304
P356
10.1080/07853890310008224
P407
P577
2003-01-01T00:00:00Z