PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.
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Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and CancerUp-regulating CYP3A4 expression in C3A cells by transfection with a novel chimeric regulator of hPXR-p53-ADNon-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylomeTo scale or not to scale: the principles of dose extrapolationA single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activatorProteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.Identification of clinically used drugs that activate pregnane X receptorsLinking empirical estimates of body burden of environmental chemicals and wellness using NHANES data.Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Pregnane X receptor-mediated induction of Cyp3a by black cohosh.Cell-based systems to assess nuclear receptor activation and their use in drug development.Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.Maternal hepatic growth response to pregnancy in the mouse.SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism.Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Nrf2 participates in regulating maternal hepatic adaptations to pregnancyXenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspectiveMolecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infectionThe Nrf2 activator oltipraz also activates the constitutive androstane receptor.PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.Identification of Ginkgo biloba as a novel activator of pregnane X receptor.Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzymeNuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR activators in human primary hepatocytes.The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumorsActivation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential.Signaling control of the constitutive androstane receptor (CAR)Ambient tonicity and intestinal cytochrome CYP3A.Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT.Nuclear receptors in bile acid metabolismAdvances in predicting CYP-mediated drug interactions in the drug discovery setting.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line.Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons.
P2860
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P2860
PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
PXR and CAR: nuclear receptors ...... osition and chemical toxicity.
@ast
PXR and CAR: nuclear receptors ...... osition and chemical toxicity.
@en
type
label
PXR and CAR: nuclear receptors ...... osition and chemical toxicity.
@ast
PXR and CAR: nuclear receptors ...... osition and chemical toxicity.
@en
prefLabel
PXR and CAR: nuclear receptors ...... osition and chemical toxicity.
@ast
PXR and CAR: nuclear receptors ...... osition and chemical toxicity.
@en
P2093
P2860
P1476
PXR and CAR: nuclear receptors ...... osition and chemical toxicity.
@en
P2093
Brian C Horsburgh
C Roland Wolf
Jillian Ross
Lesley A Stanley
Nico Scheer
P2860
P304
P356
10.1080/03602530600786232
P407
P577
2006-01-01T00:00:00Z