Irreversible inhibitors of serine, cysteine, and threonine proteases
about
sameAs
Free-solution, label-free protein-protein interactions characterized by dynamic light scatteringBeyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteinsCysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsCysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probesBiomarkers and molecular probes for cell death imaging and targeted therapeuticsDevelopment of calpain-specific inactivators by screening of positional scanning epoxide librariesStructural and Molecular Mechanism for Autoprocessing of MARTX Toxin of Vibrio cholerae at Multiple SitesCocrystal Structures of Primed Side-Extending α-Ketoamide Inhibitors Reveal Novel Calpain-Inhibitor Aromatic Interactions #Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxinNonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease ChemotherapyIn Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruziThe structural basis for catalysis and substrate specificity of a rhomboid proteaseRational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdBPeptide Length and Leaving-Group Sterics Influence Potency of Peptide Phosphonate Protease InhibitorsDefining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxinsStructural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165Chemical genetic strategy for targeting protein kinases based on covalent complementarityInsights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangementStructure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ CavityUltrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal LoopNon-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assayAutoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and CatalysisCatalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionalitySchistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitorCure of hookworm infection with a cysteine protease inhibitorMycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2An Unusual Member of the Papain Superfamily: Mapping the Catalytic Cleft of the Marasmius oreades agglutinin (MOA) with a Caspase InhibitorA Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial CytotoxicitySynthetic biology approaches to fluorinated polyketidesRoutes to covalent catalysis by reactive selection for nascent protein nucleophilesInhibition of extracellular lipase from Streptomyces rimosus with 3,4-dichloroisocoumarin.Modulation of infectivity in phage display as a tool to determine the substrate specificity of proteases.Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum.Using specificity to strategically target proteases.Identification of a new class of nonpeptidic inhibitors of cruzain.Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates.Exceptional amyloid beta peptide hydrolyzing activity of nonphysiological immunoglobulin variable domain scaffolds.Proteolysis of recombinant proteins in bioengineered plant cellsAllosteric regulation of protease activity by small molecules.Synthesis and antiproliferative activities of ottelione a analogues
P2860
Q24645138-29F15FBA-7E83-43E1-9D99-46EE2D9DE038Q24649147-CFA4BDCC-CD78-4E1C-9F52-CA39099805FDQ26771736-CC658CCE-C6D7-49CE-B24E-525E49BF7BD6Q26827307-87DC1E79-BE0C-4D1E-8528-9E4823BAA6D0Q26866387-6C04A05A-A1CE-4259-96F1-04B72D4B221FQ27643516-DD02C1C1-69A2-41C7-B9D0-BD394E6DB9C9Q27646560-D58E409A-1C6D-4035-9DFA-C431A4F19653Q27651571-7090B171-6F21-4989-8197-E84145522F36Q27655603-AB1B761F-50A9-40AB-B6A0-0CCA842C9860Q27659045-930513D5-1A1B-4AC2-96C7-00CF37CA2E4BQ27664609-4E7A821E-C631-4FC9-9AE0-CC80BAF691E9Q27664874-5C6A734C-8637-4A0C-86A9-8E812A93DDC7Q27666020-7A941C5E-94DB-422F-82A6-CACC8891E23EQ27666756-43A98921-CD51-4D88-AC3B-0E86D9BC2228Q27666963-02D458F2-13CA-40D5-87DB-8D62C4FC7C32Q27671266-57A4847C-5C09-486C-B2EB-1453912BA050Q27671824-45DEFD4D-5244-4571-AF5E-80C7B9A4F6BEQ27677100-5E9F7E9E-3194-4040-A937-F47068821663Q27678089-7361960B-0B02-4805-8A9C-FBBEB8AA8538Q27679343-5CE92709-A790-4263-9450-92B9CD38B974Q27679837-A8929C49-88D0-4C73-BD66-06194620A547Q27681206-C1BDF8A5-DDAE-4532-838C-9DC28EF608C8Q27698250-CF33D035-A520-4A1B-A5BE-BBFC3DC046B8Q28469107-3A746C17-8E13-4174-AE11-6498FB1FCECEQ28480978-52EC6802-F404-4D19-9ADE-C3D23F94C604Q28538895-40AF60B0-4CCC-42E1-A610-C7B0584E1AFFQ28550327-6FF53286-3BC3-46F2-B9EB-A42BDB13F772Q28553135-8C6F4D9D-D61A-4811-A217-FA48F1B239CBQ28834646-ABFE3105-1297-4AF7-80D8-BC1BE5AA2748Q30838921-36064C9B-1088-4EAF-A3B5-598AD6CBBE8FQ31096364-1BA98EA5-5F31-4D3C-8C9C-CEB72372EC94Q33241335-39475F5D-B47D-486B-8BCB-D60B98AC4575Q33317962-64C939BD-C0BA-41BF-A4B7-90351BD6B205Q33330575-BE273074-FE6F-4AF3-9701-CF1038FFBCB2Q33330700-4A93D054-D664-41B0-AE99-BBA8EEB3C306Q33373239-4E092F3E-707B-4478-A5F0-5FD8827F292DQ33381465-341CFD9E-6092-4908-B882-D04A95A24312Q33560054-8F97CB6B-8224-4450-95F5-92780002404AQ33601580-4E1BE5DC-2FB2-4772-8A62-3783129C56A4Q33630497-EB7054C3-0FF9-4CBB-8B6A-1D559E4A2439
P2860
Irreversible inhibitors of serine, cysteine, and threonine proteases
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Irreversible inhibitors of serine, cysteine, and threonine proteases
@ast
Irreversible inhibitors of serine, cysteine, and threonine proteases
@en
Irreversible inhibitors of serine, cysteine, and threonine proteases
@nl
type
label
Irreversible inhibitors of serine, cysteine, and threonine proteases
@ast
Irreversible inhibitors of serine, cysteine, and threonine proteases
@en
Irreversible inhibitors of serine, cysteine, and threonine proteases
@nl
prefLabel
Irreversible inhibitors of serine, cysteine, and threonine proteases
@ast
Irreversible inhibitors of serine, cysteine, and threonine proteases
@en
Irreversible inhibitors of serine, cysteine, and threonine proteases
@nl
P2093
P3181
P356
P1433
P1476
Irreversible inhibitors of serine, cysteine, and threonine proteases
@en
P2093
James C Powers
Juliana L Asgian
Karen Ellis James
Ozlem Dogan Ekici
P304
P3181
P356
10.1021/CR010182V
P407
P577
2002-12-01T00:00:00Z