Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation - Test2 - elhamkhani - TriplyDB

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

http://www.wikidata.org/entity/Q28241953

about

IgH chain class switch recombination: mechanism and regulation Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Overlapping hotspots in CDRs are critical sites for V region diversification Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress.AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination.DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.Epigenomic Modifications Mediating Antibody Maturation.APURINIC/APYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE Play Overlapping Roles in the Maintenance of Epigenome and Genome Stability

P2860

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P2860

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

http://www.wikidata.org/entity/Q28241953

description

2014 nî lūn-bûn

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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2014 թվականի հունիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Differential expression of APE ...... s during somatic hypermutation

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Differential expression of APE ...... s during somatic hypermutation

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Differential expression of APE ...... s during somatic hypermutation

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Differential expression of APE ...... s during somatic hypermutation

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Differential expression of APE ...... s during somatic hypermutation

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Differential expression of APE ...... s during somatic hypermutation

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Differential expression of APE ...... s during somatic hypermutation

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Differential expression of APE ...... s during somatic hypermutation

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Differential expression of APE ...... s during somatic hypermutation

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PNAS.1405590111

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Proceedings of the National Academy of Sciences of the United States of America

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Differential expression of APE ...... s during somatic hypermutation

@en

P2093

Anna J Ucher

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Daisuke Tsuchimoto

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Erin K Linehan

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Ghaith Habboub

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Janet Stavnezer

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Mikayla R Thompson

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Tatenda Kadungure

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P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway

SIRT1 deacetylates APE1 and regulates cellular base excision repair

XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions

Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

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9217-22

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25

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111

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Carol E. Schrader

Yusaku Nakabeppu

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2014-06-24T00:00:00Z

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263100401

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