Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
about
AID and APOBECs span the gap between innate and adaptive immunityTranscription-coupled mutagenesis by the DNA deaminase AIDHuman CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombinationOptimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repairThe RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesAID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.Internal IgH class switch region deletions are position-independent and enhanced by AID expressionSomatic hypermutation of the AID transgene in B and non-B cellsThe structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damageToll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responsesRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationMicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocationImmunoglobulin class switch recombination is impaired in Atm-deficient miceMurine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse modelEssential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytesCD20 deficiency in humans results in impaired T cell-independent antibody responsesActivation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseThe molecular pathology of primary immunodeficienciesCloning and functional characterisation of avian transcription factor E2AActivation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediateSecret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutationX-linked hyper IgM (HIGM1) in an African kindred: the first report from South AfricaMutant loxP vectors for selectable marker recycle and conditional knock-outsExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesGenetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell lineThe germinal center antibody response in health and diseaseMutations, kataegis and translocations in B cells: understanding AID promiscuous activityThe evolution within usHumoral immunodeficiency : awareness for better supportThe genetic landscape of diffuse large B-cell lymphomaDiseases associated with defective responses to DNA damageRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationIgH chain class switch recombination: mechanism and regulationEtoposide induces nuclear re-localisation of AIDHepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human AntibodyAID targeting is dependent on RNA polymerase II pausing.
P2860
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P2860
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@ast
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@en
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@en-gb
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
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type
label
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@ast
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@en
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@en-gb
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@nl
prefLabel
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@ast
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@en
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@en-gb
Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@nl
P2093
P50
P3181
P1433
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Activation-induced cytidine de ...... the Hyper-IgM syndrome (HIGM2)
@en
P2093
A G Ugazio
F Geissmann
H Kayserili
K Kinoshita
L D Notarangelo
M Forveille
P304
P3181
P356
10.1016/S0092-8674(00)00079-9
P407
P577
2000-09-01T00:00:00Z