Candidate gene for the chromosome 1 familial Alzheimer's disease locus
about
Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1Vitamin A and Alzheimer's diseaseThe genetic epidemiology of neurodegenerative disease.Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor proteinThe familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta productionSEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide productionInteraction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseasePresenilin 1 associates with glycogen synthase kinase-3beta and its substrate tauGeneration of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavageRole of presenilin 1 in structural plasticity of cortical dendritic spines in vivoThe apolipoprotein E gene, attention, and brain functionA scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residueAlzheimer disease: new concepts on its neurobiology and the clinical role imaging will playPathways towards and away from Alzheimer's diseaseSelective inhibition of Alzheimer disease-like tau aggregation by phenothiazinesCurcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryInteraction of presenilins with the filamin family of actin-binding proteinsPhosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosisWhen loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseaseThe amyloid precursor protein: beyond amyloidlin-12 Notch functions in the adult nervous system of C. elegans.Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunctionAmyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta poresIntracellular Calcium Dysregulation: Implications for Alzheimer's DiseaseMolecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and PhosphorylationMouse Genetic Models of Human Brain DisordersMetals and Neuronal Metal Binding Proteins Implicated in Alzheimer's DiseaseImplications of GABAergic Neurotransmission in Alzheimer's DiseaseTau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective StrategiesA Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease PathogenesisThe genetic landscape of Alzheimer disease: clinical implications and perspectivesMutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disordersThe role of large pedigrees in an era of high-throughput sequencingCaenorhabditis elegans as a model organism to study APP functionMitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic interventionEpidemiology of Alzheimer diseaseAutophagy and neurodegenerationGenetic heterogeneity in Alzheimer disease and implications for treatment strategiesThe genetics and neuropathology of Alzheimer's disease
P2860
Q22010752-285CD86E-6BCE-4F8D-8BBD-6B444A77A564Q22242414-EE347593-3664-4E3E-AC57-A3820A8433A3Q22306301-38A0B9EC-A47F-45A4-94A0-324206A51D9FQ24305128-FE9D6AC8-02C9-4A66-83EB-7EBD0DE2C8F5Q24306233-C5B5099D-C05E-407E-A48D-6459CBA694DBQ24307854-E5F18ABF-BE22-427D-800F-E38249DF1EC9Q24317439-2137ACE1-C03D-43AB-ADFB-F181D2B5FBD3Q24320124-A71314B2-B177-4C26-AF53-A3110AC083B7Q24322944-F49D2C77-23DE-4EF3-A28C-60A00D4CFE89Q24338802-9C685967-9BBA-4053-9216-E33E4D4A0626Q24539024-E74170A6-F496-4B03-8E4A-45BCBD82A62CQ24540512-B8646A25-8770-443F-AFEB-AFD8EAE8765DQ24564792-BC262BF7-BCA6-40D4-97AA-B8CAC784A151Q24594531-DDAA4224-B1A0-457C-85DF-4AA28FF03232Q24596270-3DD1F7C7-48C2-4E42-9342-589690B4CADDQ24598853-FC3CE1A2-830D-4A18-BE29-2A3187893677Q24630927-360D44C9-5A54-4FAC-B2D9-297A1D55E9EEQ24674595-D8CEE523-0C8C-47A5-B430-8DC568098EA9Q24675701-7C1C4040-C9D6-4528-B3B3-725D5AD6EA40Q24676480-4CB05AB6-DEAB-4FE5-BDC3-E3E458184300Q24680465-3C95CA6A-6871-4F1D-A5ED-A090B09E8DF7Q24815573-732529FC-006B-4795-BFC0-3946D257AC65Q26269903-83BB7D8B-793E-43F5-BE88-019F37A6F305Q26738355-84202076-A585-427B-897D-087ED2EDB358Q26747203-49A2D33C-A28E-4E5B-8773-0779C7712978Q26748105-F5A06963-AFB1-42B4-8910-6DBAABBCB97CQ26752246-BC25C883-C4B3-4A63-B271-A6FF8F1FBD63Q26765782-C89C6586-5118-44EB-A2AB-CCF0B2905E36Q26768593-4B1ECAF7-3466-48DD-A4EC-913E4AF79D9CQ26769957-9E592B7B-ECF1-4D16-BF25-0F5E78467E64Q26781496-35A9E641-C932-46C9-9B10-A2E6EBB9F1CDQ26796582-7300804F-E9E1-4236-8E6D-AB193D599D26Q26800286-6EA3587E-3F0D-428B-8F00-EC82C646081EQ26825546-B3603BFA-63F2-4935-9A40-33FA825894ADQ26851244-05C9EFC0-8624-447A-BB4D-6F078A858B7CQ26865358-BD38609F-8A45-4AF5-BC22-2E1990713469Q26865371-ED039E21-D4E0-41B6-BE9F-85917FD5827DQ26991692-A582D6AA-CF5C-47CD-82C8-CD5C25B7ABA0Q26995802-F061EB3E-D9B1-49B9-B722-E8B2E1D69B59Q26998097-27890B89-16BF-4704-A20E-7248D2A2056D
P2860
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@ast
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@en
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@nl
type
label
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@ast
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@en
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@nl
prefLabel
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@ast
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@en
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@nl
P2093
P2860
P3181
P356
P1433
P1476
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
@en
P2093
D M Romano
E Levy-Lahad
P D Jondro
S D Schmidt
W H Pettingell
P2860
P3181
P356
10.1126/SCIENCE.7638622
P407
P577
1995-08-18T00:00:00Z