Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors" - Test2 - elhamkhani - TriplyDB

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"

http://www.wikidata.org/entity/Q28246814

about

Crystal structure of human CDK4 in complex with a D-type cyclin CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.Regulation of CDK4 Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation.The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.CDK4: A Key Player in the Cell Cycle, Development, and Cancer The CDK Network: Linking Cycles of Cell Division and Gene Expression.A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G 2/M phases of the cell cycle.PRMT5 competitively binds to CDK4 to promote G1-S transition upon glucose induction in hepatocellular carcinoma.Signaling through cyclin D-dependent kinases.Hyperosmotic stress induces cell cycle arrest in retinal pigmented epithelial cells.Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21.CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib.p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.Protein O-glucosyltransferase 1 overexpression downregulates p16 in BT474 human breast cancer cells.Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases.Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6

P2860

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P2860

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"

http://www.wikidata.org/entity/Q28246814

description

2006 nî lūn-bûn

@nan

2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@ast

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@en

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@nl

type

label

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@ast

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@en

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@nl

prefLabel

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@ast

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@en

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@nl

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P2860

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P356

P1433

Molecular and Cellular Biology

P1476

Regulated activating Thr172 ph ...... h cyclins and CDK "inhibitors"

@en

P2093

Frederick Libert

http://www.w3.org/2001/XMLSchema#string

Hugues Kooken

http://www.w3.org/2001/XMLSchema#string

Jacques E Dumont

http://www.w3.org/2001/XMLSchema#string

Katia Coulonval

http://www.w3.org/2001/XMLSchema#string

Laurence Bockstaele

http://www.w3.org/2001/XMLSchema#string

Pierre P Roger

http://www.w3.org/2001/XMLSchema#string

Sabine Paternot

http://www.w3.org/2001/XMLSchema#string

P2860

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

New functional activities for the p21 family of CDK inhibitors

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

Cyclin C/cdk3 promotes Rb-dependent G0 exit

Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase

P304

5070-85

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.02006-05

http://www.w3.org/2001/XMLSchema#string

P407

P433

13

http://www.w3.org/2001/XMLSchema#string

P478

26

http://www.w3.org/2001/XMLSchema#string

P50

Yvan de Launoit

P577

2006-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7000811

http://www.w3.org/2001/XMLSchema#string

P698

16782892

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

1489149

http://www.w3.org/2001/XMLSchema#string