Identification of specific PP2A complexes involved in human cell transformation
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P1343
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERKThe tumor suppressor PP2A Abeta regulates the RalA GTPaseA PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) proteinIdentification of PP2A complexes and pathways involved in cell transformationIdentification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cyclePP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulumLeucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cellsHuman Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulatorG1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemiaTargeting protein serine/threonine phosphatases for drug developmentThe broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillanceProtein Phosphatase 2A as a Therapeutic Target in Acute Myeloid LeukemiaPPP2R5C Couples Hepatic Glucose and Lipid HomeostasisStructural Basis of PP2A Inhibition by Small t AntigenPP2A: The Wolf in Sheep's Clothing?Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytesProtein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome DegradationThe alpha4-containing form of protein phosphatase 2A in liver and hepatic cells.TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activitySimian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor.Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bδ gene.Heterogeneous nuclear ribonucleoprotein A2 is a SET-binding protein and a PP2A inhibitor.Identification of a novel conserved mixed-isoform B56 regulatory subunit and spatiotemporal regulation of protein phosphatase 2A during Xenopus laevis development.Modeling the role of p53 pulses in DNA damage- induced cell death decision.Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation.Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.Transformation of human and murine fibroblasts without viral oncoproteins.Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.The B56gamma3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition.A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2APP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length.Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.Heavy metal-induced metallothionein expression is regulated by specific protein phosphatase 2A complexes.Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in miceEssential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancersEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis.A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.
P2860
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P2860
Identification of specific PP2A complexes involved in human cell transformation
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Identification of specific PP2A complexes involved in human cell transformation
@ast
Identification of specific PP2A complexes involved in human cell transformation
@en
Identification of specific PP2A complexes involved in human cell transformation
@nl
type
label
Identification of specific PP2A complexes involved in human cell transformation
@ast
Identification of specific PP2A complexes involved in human cell transformation
@en
Identification of specific PP2A complexes involved in human cell transformation
@nl
prefLabel
Identification of specific PP2A complexes involved in human cell transformation
@ast
Identification of specific PP2A complexes involved in human cell transformation
@en
Identification of specific PP2A complexes involved in human cell transformation
@nl
P2093
P3181
P1433
P1476
Identification of specific PP2A complexes involved in human cell transformation
@en
P2093
Courtney A Plattner
David C Pallas
K Thirza Campbell
William C Hahn
P304
P3181
P356
10.1016/S1535-6108(04)00026-1
P407
P4510
P577
2004-02-01T00:00:00Z