ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells - Test2 - elhamkhani - TriplyDB

ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells

ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells

http://www.wikidata.org/entity/Q24651299

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The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein UHRF1 plays a role in maintaining DNA methylation in mammalian cells Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth.The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1 Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle Functional dissection of the role of UHRF1 in the regulation of retinoblastoma methylome.UHRF1 is a novel diagnostic marker of lung cancer.Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases.Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression.Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties Increased glutamine in leaves of poplar transgenic with pine GS1a caused greater anthranilate synthetase α-subunit (ASA1) transcript and protein abundances: an auxin-related mechanism for enhanced growth in GS transgenics?DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3'-end GC density.Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1 UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis.S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation.Effects of Auraptene on IGF-1 Stimulated Cell Cycle Progression in the Human Breast Cancer Cell Line, MCF-7.Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus.UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development.Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition.The PHD domain of Np95 (mUHRF1) is involved in large-scale reorganization of pericentromeric heterochromatin Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1).UHRF1 gene silencing inhibits cell proliferation and promotes cell apoptosis in human cervical squamous cell carcinoma CaSki cells.Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system.UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer.UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance.Regulation of maintenance DNA methylation via histone ubiquitylation.MiR-124 exerts tumor suppressive functions on the cell proliferation, motility and angiogenesis of bladder cancer by fine-tuning UHRF1.PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311.Up-regulation of UHRF1 by oncogenic Ras promoted the growth, migration, and metastasis of pancreatic cancer cells.The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis

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P2860

ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells

http://www.wikidata.org/entity/Q24651299

description

2003 nî lūn-bûn

@nan

2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հուլիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

@zh-hk

2003年論文

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2003年論文

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2003年论文

@wuu

name

ICBP90 belongs to a new family ...... is deregulated in cancer cells

@ast

ICBP90 belongs to a new family ...... is deregulated in cancer cells

@en

ICBP90 belongs to a new family ...... is deregulated in cancer cells

@nl

type

label

ICBP90 belongs to a new family ...... is deregulated in cancer cells

@ast

ICBP90 belongs to a new family ...... is deregulated in cancer cells

@en

ICBP90 belongs to a new family ...... is deregulated in cancer cells

@nl

prefLabel

ICBP90 belongs to a new family ...... is deregulated in cancer cells

@ast

ICBP90 belongs to a new family ...... is deregulated in cancer cells

@en

ICBP90 belongs to a new family ...... is deregulated in cancer cells

@nl

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British Journal of Cancer

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ICBP90 belongs to a new family ...... is deregulated in cancer cells

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B Louis

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M Jeanblanc

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M Mousli

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P Oudet

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R Hopfner

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P2860

NIRF, a novel RING finger protein, is involved in cell-cycle regulation

ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression

Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1

Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression

Transcriptional regulation of the human topoisomerase IIalpha gene

Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbeta

Mimosine arrests cells in G1 by enhancing the levels of p27(Kip1)

Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation

DNA topoisomerases

Transcriptional regulation of topoisomerase II alpha at confluence and pharmacological modulation of expression by bis-benzimidazole drugs.

P2888

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120-127

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scholarly article

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44326

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10.1038/SJ.BJC.6601068

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1

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89

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Christian Bronner

Abdul Qader Abbady

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2003-07-01T00:00:00Z

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1021667517

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12838312

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2394215

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