Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action - Test2 - elhamkhani - TriplyDB

Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action

Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action

http://www.wikidata.org/entity/Q28270149

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Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology Effect of natural and semisynthetic pseudoguianolides on the stability of NF-κB:DNA complex studied by agarose gel electrophoresis Identification of repurposed small molecule drugs for chordoma therapy.High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.Paradigm shift in toxicity testing and modeling.Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells Finding promiscuous old drugs for new uses.Nuclear factor-κB activation in Schwann cells regulates regeneration and remyelination.Quantitative high-throughput drug screening identifies novel classes of drugs with anticancer activity in thyroid cancer cells: opportunities for repurposing The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform.Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae.Small-molecule inhibition of inflammatory β-cell death.The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform.3,4-Dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages.Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor.Identification of known drugs targeting the endoplasmic reticulum stress response.The role of tumour necrosis factor-α and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity.Phenotypic screens as a renewed approach for drug discovery.Inhibition of Survivin with YM155 Induces Durable Tumor Response in Anaplastic Thyroid Cancer.Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells.Pharmacodynamic modeling of combined chemotherapeutic effects predicts synergistic activity of gemcitabine and trabectedin in pancreatic cancer cells Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling.Sunitinib enhances neuronal survival in vitro via NF-κB-mediated signaling and expression of cyclooxygenase-2 and inducible nitric oxide synthase.Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132 Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia Assessment of the antitumor potential of Bithionol in vivo using a xenograft model of ovarian cancer.Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-κB pathway via estrogen receptor signaling.Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action.Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis Identifying regulatory mechanisms underlying tumorigenesis using locus expression signature analysis.Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastatic melanoma: basic and clinical aspects Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours.Repurposing some older drugs that cross the blood-brain barrier and have potential anticancer activity to provide new treatment options for glioblastoma.

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Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action

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2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Identification of known drugs ...... and their mechanism of action

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Identification of known drugs ...... and their mechanism of action

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Identification of known drugs ...... and their mechanism of action

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Identification of known drugs ...... and their mechanism of action

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Identification of known drugs ...... and their mechanism of action

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Identification of known drugs ...... and their mechanism of action

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Identification of known drugs ...... and their mechanism of action

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J.BCP.2009.12.021

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Biochemical Pharmacology

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Identification of known drugs ...... and their mechanism of action

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Danielle Van Leer

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Matias S Attene-Ramos

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Menghang Xia

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Paul Shinn

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Ruili Huang

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William Leister

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P2860

The NF-kappa B and I kappa B proteins: new discoveries and insights

Compound Management for Quantitative High-Throughput Screening

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Regulation and function of IKK and IKK-related kinases

Introduction to NF-kappaB: players, pathways, perspectives

Inactivation of NF-kappaB components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues

Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cells.

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Compound cytotoxicity profiling using quantitative high-throughput screening.

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.

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1272-80

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4138662

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