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Two faces of brd4: mitotic bookmark and transcriptional lynchpin

Two faces of brd4: mitotic bookmark and transcriptional lynchpin

http://www.wikidata.org/entity/Q28278777

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Epigenetics and inheritance of phenotype variation in livestock Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery Targeting BET bromodomains for cancer treatment Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target.Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin.The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells P-TEFb Kinase Activity Is Essential for Global Transcription, Resumption of Meiosis and Embryonic Genome Activation in Pig.Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division.Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction.Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction.Current understanding of the role of the Brd4 protein in the papillomavirus lifecycle.Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer.Epigenetic regulation of EBV and KSHV latency The oxygenase Jmjd6--a case study in conflicting assignments.BET inhibitors: a novel epigenetic approach.Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer.The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC.BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.New role for histone deacetylase 9 in atherosclerosis and inflammation.Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4.Dual inhibition of BRD4 and PI3K-AKT by SF2523 suppresses human renal cell carcinoma cell growth.

P2860

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P2860

Two faces of brd4: mitotic bookmark and transcriptional lynchpin

http://www.wikidata.org/entity/Q28278777

description

2013 nî lūn-bûn

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2013 թուականին հրատարակուած գիտական յօդուած

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2013 թվականին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Two faces of brd4: mitotic bookmark and transcriptional lynchpin

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Two faces of brd4: mitotic bookmark and transcriptional lynchpin

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Two faces of brd4: mitotic bookmark and transcriptional lynchpin

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Two faces of brd4: mitotic bookmark and transcriptional lynchpin

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Two faces of brd4: mitotic bookmark and transcriptional lynchpin

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Two faces of brd4: mitotic bookmark and transcriptional lynchpin

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prefLabel

Two faces of brd4: mitotic bookmark and transcriptional lynchpin

@ast

Two faces of brd4: mitotic bookmark and transcriptional lynchpin

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Two faces of brd4: mitotic bookmark and transcriptional lynchpin

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Two faces of brd4: mitotic bookmark and transcriptional lynchpin

@en

P2093

Ballachanda N Devaiah

http://www.w3.org/2001/XMLSchema#string

Dinah S Singer

http://www.w3.org/2001/XMLSchema#string

P2860

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

Selective inhibition of BET bromodomains

Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

Suppression of inflammation by a synthetic histone mimic

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain

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13-7

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scholarly article

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24809

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10.4161/TRNS.22542

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1

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23131666

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