Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation
about
Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expressionPKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complexCharacterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D geneMdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamicsMechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length constructThe protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmiasMolecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylationThe MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling moduleMolecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoformSelective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiationPhosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex.Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.PDE4 as a target for cognition enhancementPhosphodiesterases in neurodegenerative disordersCompartmentalization of β-adrenergic signals in cardiomyocytesThe role of ventral striatal cAMP signaling in stress-induced behaviors.The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulationsIntrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylationThe human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domainsGenomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domainsAssociation with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibitionERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regionsIn vitro PKA phosphorylation-mediated human PDE4A4 activationIdentification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variantsTAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acidRACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertionPhosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in StriatumPhosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterasesSubcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylationNovel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylationAttenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytesImpaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient miceAKAP signalling complexes: focal points in space and timePivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts.
P2860
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P2860
Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation
description
1996 nî lūn-bûn
@nan
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Phosphorylation and activation ...... ne 54 in the enzyme activation
@ast
Phosphorylation and activation ...... ne 54 in the enzyme activation
@en
Phosphorylation and activation ...... ne 54 in the enzyme activation
@nl
type
label
Phosphorylation and activation ...... ne 54 in the enzyme activation
@ast
Phosphorylation and activation ...... ne 54 in the enzyme activation
@en
Phosphorylation and activation ...... ne 54 in the enzyme activation
@nl
prefLabel
Phosphorylation and activation ...... ne 54 in the enzyme activation
@ast
Phosphorylation and activation ...... ne 54 in the enzyme activation
@en
Phosphorylation and activation ...... ne 54 in the enzyme activation
@nl
P356
P1476
Phosphorylation and activation ...... ne 54 in the enzyme activation
@en
P2093
P304
16526-16534
P356
10.1074/JBC.271.28.16526
P407
P577
1996-07-01T00:00:00Z