Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level
about
Wnt signaling pathways in urological cancers: past decades and still growingMessing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutationsThe APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phaseIdentification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cellsI-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coliAll Tcf HMG box transcription factors interact with Groucho-related co-repressorsInhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting proteinCrystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complexThe links between axin and carcinogenesisEpidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liverThe more the messier: centrosome amplification as a novel biomarker for personalized treatment of colorectal cancersFrizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signalingAXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancersReactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signalingCadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signalingSomatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activityInteraction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction.Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and developmentdifferent Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coliPhosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stabilityWnt-induced dephosphorylation of axin releases beta-catenin from the axin complexInteraction among GSK-3, GBP, axin, and APC in Xenopus axis specificationWnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion.Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration.Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy.Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells.Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions.Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways.The adenomatous polyposis coli protein.Analysis of Wnt signaling β-catenin spatial dynamics in HEK293T cells.Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells.Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytesAcupuncture and moxibustion reduces neuronal edema in Alzheimer's disease rats.Formation of extra centrosomal structures is dependent on beta-catenin.Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas.Beta-catenin signaling in hepatic development and progenitors: which way does the WNT blow?
P2860
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P2860
Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@ast
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@en
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@nl
type
label
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@ast
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@en
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@nl
prefLabel
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@ast
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@en
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@nl
P2093
P2860
P3181
P1433
P1476
Axin, an inhibitor of the Wnt ...... reduces the beta-catenin level
@en
P2093
K Kawahara
K Toyoshima
T Ishidate
T Nakamura
P2860
P304
P356
10.1046/J.1365-2443.1998.00198.X
P407
P577
1998-06-01T00:00:00Z