Metabolic modulation of glioblastoma with dichloroacetate - Test2 - elhamkhani - TriplyDB

Metabolic modulation of glioblastoma with dichloroacetate

Metabolic modulation of glioblastoma with dichloroacetate

http://www.wikidata.org/entity/Q28282255

about

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study Novel drugs that target the metabolic reprogramming in renal cell cancer Role of Redox Status in Development of Glioblastoma SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?The Efficacy of Ketogenic Diet and Associated Hypoglycemia as an Adjuvant Therapy for High-Grade Gliomas: A Review of the Literature Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect Is cancer a metabolic disease?What is good for the circulation also lessens cancer risk Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease Restoration of mitochondria function as a target for cancer therapy Novel therapeutic targets of tumor metabolism Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate The emerging paradigm of network medicine in the study of human disease Short-Term Differentiation of Glioblastoma Stem Cells Induces Hypoxia Tolerance.Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket Heterogeneity of glycolysis in cancers and therapeutic opportunities.The Warburg effect: 80 years on The role of Fatty Acid oxidation in the metabolic reprograming of activated t-cells Adipose tissue dysfunction and its effects on tumor metabolism Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma Chemical metabolic inhibitors for the treatment of blood-borne cancers Pro-haloacetate Nanoparticles for Efficient Cancer Therapy via Pyruvate Dehydrogenase Kinase Modulation Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure.Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature 1,25-dihydroxyvitamin D regulation of glucose metabolism in Harvey-ras transformed MCF10A human breast epithelial cells Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism

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Metabolic modulation of glioblastoma with dichloroacetate

http://www.wikidata.org/entity/Q28282255

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Metabolic modulation of glioblastoma with dichloroacetate

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Metabolic modulation of glioblastoma with dichloroacetate

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Metabolic modulation of glioblastoma with dichloroacetate

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type

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Metabolic modulation of glioblastoma with dichloroacetate

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Metabolic modulation of glioblastoma with dichloroacetate

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Metabolic modulation of glioblastoma with dichloroacetate

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Metabolic modulation of glioblastoma with dichloroacetate

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Metabolic modulation of glioblastoma with dichloroacetate

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Metabolic modulation of glioblastoma with dichloroacetate

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SCITRANSLMED.3000677

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Science Translational Medicine

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Metabolic modulation of glioblastoma with dichloroacetate

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A Haromy

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B Abdulkarim

http://www.w3.org/2001/XMLSchema#string

C Maguire

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D Fulton

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E D Michelakis

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E Niven

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G Sutendra

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K C Petruk

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L Webster

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M S McMurtry

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P2860

Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Role of dichloroacetate in the treatment of genetic mitochondrial diseases

IDH1 and IDH2 mutations in gliomas

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

Targeting HIF-1 for cancer therapy

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

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100571

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10.1126/SCITRANSLMED.3000677

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20463368

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dichloroacetate