Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors
about
Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorderRecent advances in the neuropsychopharmacology of serotonergic hallucinogensFluorine in psychedelic phenethylaminesPsychedelicsPharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategyFunctional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT)Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity.Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction.Teaching old receptors new tricks: biasing seven-transmembrane receptors.Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2C receptors.Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats.Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response.Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivoFine-tuning serotonin2c receptor function in the brain: molecular and functional implicationsSerotonin 5-HT₂ receptor activation prevents allergic asthma in a mouse modelNeuroreceptor activation by vibration-assisted tunneling.Drug discovery targeting human 5-HT(2C) receptors: residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formationPhospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortexNeurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient micePeptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptorsSupport for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response modelRole of the 5-HT₂A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice.Behavioral and neurochemical pharmacology of six psychoactive substituted phenethylamines: mouse locomotion, rat drug discrimination and in vitro receptor and transporter binding and function.How much do we know about the coupling of G-proteins to serotonin receptors?A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment.Signalling profile differences: paliperidone versus risperidone.An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice.Effect of Hallucinogens on Unconditioned Behavior.Designer psychostimulants in urine by liquid chromatography-tandem mass spectrometry.Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles.Evaluation of the abuse potential of lorcaserin, a serotonin 2C (5-HT2C) receptor agonist, in recreational polydrug users.Neuroendocrine Associations Underlying the Persistent Therapeutic Effects of Classic Serotonergic Psychedelics.Acute Pharmacological Effects of 2C-B in Humans: An Observational Study.Making Sense of Pharmacology: Inverse Agonism and Functional Selectivity25B-NBOMe and its precursor 2C-B: modern trends and hidden dangers
P2860
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P2860
Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors
description
2007 nî lūn-bûn
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2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
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2007年の論文
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2007年学术文章
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2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@ast
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@en
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@nl
type
label
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@ast
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@en
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@nl
prefLabel
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@ast
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@en
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@nl
P2093
P356
P1476
Functional selectivity of hall ...... (5-HT)2A and 5-HT2C receptors
@en
P2093
Bruce K Cassels
Kelly A Berg
Manuel A Gutiérrez-Hernandez
Miguel Reyes-Parada
Patricio Sáez-Briones
William P Clarke
P304
P356
10.1124/JPET.106.117507
P407
P50
P577
2007-03-02T00:00:00Z