Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice - Test2 - elhamkhani - TriplyDB

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

http://www.wikidata.org/entity/Q28300013

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Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion Diseases The unfolded protein response in multiple sclerosis Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response The unfolded protein response in neurodegenerative diseases: a neuropathological perspective The mechanistic basis of arsenicosis: pathogenesis of skin cancer Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury Treatment of Prion Disease with Heterologous Prion Proteins Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP Autophagy: an adaptive physiological countermeasure to cellular senescence and ischaemia/reperfusion-associated cardiac arrhythmias Crosstalk between the unfolded protein response and NF-κB-mediated inflammation in the progression of chronic kidney disease Prion Diseases Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory Tumor progression and the different faces of the PERK kinase Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?Drosophila as an In Vivo Model for Human Neurodegenerative Disease Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases From structure to redox: The diverse functional roles of disulfides and implications in disease.RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease.Insights into the architecture of the eIF2Bα/β/δ regulatory subcomplex Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.Endoplasmic reticulum stress and inflammation in the central nervous system Chemical probes targeting epigenetic proteins: Applications beyond oncology.Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.PERK: a novel therapeutic target for neurodegenerative diseases?Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis.Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy.Mouse models for studying the formation and propagation of prions.PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.Successes and challenges in phenotype-based lead discovery for prion diseases Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases.Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis.PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.

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P2860

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

http://www.wikidata.org/entity/Q28300013

description

2013 nî lūn-bûn

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2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2013年の論文

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2013年論文

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2013年论文

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SCITRANSLMED.3006767

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Science Translational Medicine

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Oral treatment targeting the u ...... disease in prion-infected mice

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Anne E Willis

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Catharine A Ortori

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Helois Radford

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Jeffrey M Axten

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Julie A Moreno

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Mark Halliday

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Nicholas Verity

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P2860

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

Signal integration in the endoplasmic reticulum unfolded protein response

Adapting proteostasis for disease intervention

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction

Regulated translation initiation controls stress-induced gene expression in mammalian cells

Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease.

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Peter M. Fischer

David A. Barrett

Giovanna R Mallucci

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2013-10-09T00:00:00Z

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257549616

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24107777

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Prion protein family