SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation - Test2 - elhamkhani - TriplyDB

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

http://www.wikidata.org/entity/Q28302907

about

Sequential replication-coupled destruction at G1/S ensures genome stability.Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate The emerging role of lysine methyltransferase SETD8 in human diseases Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL 14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.Chromatin replication and epigenome maintenance.Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Proteome identification of proteins interacting with histone methyltransferase SET8.Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control.Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin.C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint.SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma Small molecule therapeutics targeting F-box proteins in cancer.Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time.Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase H4K20 methylation regulates quiescence and chromatin compaction.Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20 The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies.CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases SET for life: biochemical activities and biological functions of SET domain-containing proteins A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing.COP9 signalosome function in the DDR.Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!Ub-family modifications at the replication fork: Regulating PCNA-interacting components.Lysine methylation: beyond histones.CRL Ubiquitin Ligases and DNA Damage Response.

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SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

http://www.wikidata.org/entity/Q28302907

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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name

SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

@ast

SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

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SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

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type

label

SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

@ast

SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

@en

SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

@nl

prefLabel

SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

@ast

SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

@en

SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

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SET8 is degraded via PCNA-coup ...... phase and after UV irradiation

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Lisbeth Hansen

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Morten Eskildsen

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Randi G Syljuåsen

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Stine Jørgensen

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P2860

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

L3MBTL1, a histone-methylation-dependent chromatin lock

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Modulation of p53 function by SET8-mediated methylation at lysine 382

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

The DNA-damage response in human biology and disease

Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase

Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.

The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure

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10.1083/JCB.201009076

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1

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192

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Morten Beck Trelle

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Marie Sofie Yoo Larsen

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49742102

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21220508

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