PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
about
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesisSelective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrateA mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradationRNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.Functions of Ubiquitin and SUMO in DNA Replication and Replication StressPR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcriptionSequential replication-coupled destruction at G1/S ensures genome stability.Examination of the expanding pathways for the regulation of p21 expression and activity.A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BEssential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesisA novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phaseSET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiationThe tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progressionA novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycleGenetic abolishment of hepatocyte proliferation activates hepatic stem cellsCUL4A abrogation augments DNA damage response and protection against skin carcinogenesisTranscriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanismThe ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activityThe E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradationDegradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNACRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factorNEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cellsCRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradationThe SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.CRL4Cdt2: master coordinator of cell cycle progression and genome stabilityp21 in cancer: intricate networks and multiple activitiesDNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.The Control of Arabidopsis thaliana Growth by Cell Proliferation and Endoreplication Requires the F-Box Protein FBL17.CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cellsThe DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation.14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer.
P2860
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P248
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P2860
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
PCNA-dependent regulation of p ...... 4Cdt2 ubiquitin ligase complex
@nl
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@ast
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@en
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@en-gb
type
label
PCNA-dependent regulation of p ...... 4Cdt2 ubiquitin ligase complex
@nl
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@ast
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@en
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@en-gb
prefLabel
PCNA-dependent regulation of p ...... 4Cdt2 ubiquitin ligase complex
@nl
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@ast
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@en
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@en-gb
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
PCNA-dependent regulation of p ...... Cdt2 ubiquitin ligase complex.
@en
P2093
Kenta Terai
Uma Sivaprasad
Virginia Amador
P2860
P304
P3181
P356
10.1101/GAD.1676108
P407
P577
2008-09-01T00:00:00Z