Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase - Test2 - elhamkhani - TriplyDB

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

http://www.wikidata.org/entity/Q35237385

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Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms Regulation of Unperturbed DNA Replication by Ubiquitylation Endoreplication and polyploidy: insights into development and disease Building and remodelling Cullin-RING E3 ubiquitin ligases A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability The emerging role of lysine methyltransferase SETD8 in human diseases Ubiquitylation, neddylation and the DNA damage response A novel cell permeable DNA replication and repair marker Gain of function in CDKN1C PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL USP7 is a SUMO deubiquitinase essential for DNA replication CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1 14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNA Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.The Control of Arabidopsis thaliana Growth by Cell Proliferation and Endoreplication Requires the F-Box Protein FBL17.A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells.Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication.Thymine DNA glycosylase is a CRL4Cdt2 substrate.Towards long term cultivation of Drosophila wing imaginal discs in vitro.The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues.Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.Interrogating the function of metazoan histones using engineered gene clusters.Replisome function during replicative stress is modulated by histone h3 lysine 56 acetylation through Ctf4.Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells Mitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.

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P2860

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

http://www.wikidata.org/entity/Q35237385

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

@ast

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

@en

type

label

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

@ast

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

@en

prefLabel

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

@ast

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

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Genes & Development

P1476

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

@en

P2093

Courtney G Havens

http://www.w3.org/2001/XMLSchema#string

Johannes C Walter

http://www.w3.org/2001/XMLSchema#string

P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

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1568-1582

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scholarly article

P356

10.1101/GAD.2068611

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15

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25

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2011-08-01T00:00:00Z

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51558587

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21828267

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3182024

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